Fluorinated MOFs Products

Leading Fluorinated MOFs to Help Your Research and Industrial Upgrade!

The remarkable properties of metal-organic frameworks (MOFs), such as highly tunable structures, chemical diversity, high specific surface areas, and tunable pore sizes, make them of vital importance to the field of materials science. Fluorinated Metal-Organic Frameworks (F-MOFs) are a class of materials that functionalize metal-organic frameworks (MOFs) by introducing fluorine atoms or fluorinated groups. The benefits of these materials include both their large surface area and their superior stability in water and various acidic and alkaline conditions compared to non-fluorinated MOFs. Alfa Chemistry offers customers extensive options of F-MOFs to help them find the best product for their applications.

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Advantages of Fluorination in MOFs

Hydrophobicity

Fluorination creates hydrophobic surfaces by:

Introducing non-polar C-F groups that repel water molecules.

Fluorinated ligands enhance the hydrophobicity of MOFs by introducing hydrophobic fluorine atoms, thus reducing the interaction between water molecules and MOFs. The hydrophobic effect blocks water molecules from accessing MOF pore channels, which increases their stability when exposed to water.

Reducing hydrogen-bonding sites on pore walls.

For example, UiO-66-(F4) adsorbs 470 mg/g of perfluorinated pollutants (PFOS/PFOA) via fluorine-fluorine interactions, while maintaining structural stability in aqueous environments. The application of surface fluorination methods, including polymer coatings, bolsters water resistance while keeping pore access intact.

Enhanced Stability

Thermal Stability

Fluorinated ligands (e.g., H₂-F₄BDC) stabilize frameworks by increasing bond dissociation energy. Al-MIL-53-F4 shows reversible phase transitions between 220-225°C, a narrower range than its non-fluorinated counterpart.

Chemical Stability

The electron-withdrawing nature of fluorine helps safeguard metal nodes against hydrolysis. The material DNL-9(Fe), which contains fluorinated Fe-F-Fe nodes, shows stable performance during the separation of C₂H₂/CO₂ in the presence of moisture.

Tunable Properties

Fluorine enables precise property modulation:

Pore Environment

Adjusting fluorine content and position alters pore polarity. Fe-PF1 (single-F) and Fe-PF4 (tetra-F) exhibit distinct CO₂ adsorption capacities (3.2 vs. 2.8 mol/g) due to varying F···CO₂ dipole interactions.

Catalytic Activity

Fluorinated ligands (e.g., Zr6-fBDC) enhance Lewis acidity, boosting catalytic efficiency in Diels-Alder reactions by 10-fold compared to non-fluorinated UiO-66.

Selective Adsorption

Fluorinated ZJU-800 achieves 99.9% C₂H₂ purity in gas mixtures via fluorine-mediated hydrogen bonding.

Customers Often Look For

Alfa Chemistry is a leader in providing high-quality fluorinated MOFs for a variety of industrial applications. Our best-selling fluorinated MOF products are trusted by professionals for their unmatched performance and versatility. Click on the links below to explore products that fit your needs. If you don't see your product here, we can still custom synthesize it.

MIL-100 (Fe)

OFC1195763371

NH2-MIL-101 (Cr)

OFC1414869956

SIFSIX-2-Cu-i

OFC1428136871

KAUST-7

OFC1973399073

SIFSIX-1-Cu

OFC288297892

MIL-100 (Cr)

OFC840523888

MIL-101 (Cr)

OFC869288095

MIL-100 (Fe)

Catalog: OFC1195763371

CAS Number: 1195763-37-1

Unit Molecular Formula: C18O15FFe3

Unit Molecular Weight: 642.72

NH2-MIL-101 (Cr)

Catalog: OFC1414869956

CAS Number: 1414869-95-6

Unit Molecular Formula: C24N3O15FCr3

Unit Molecular Weight: 745.25

SIFSIX-2-Cu-i

Catalog: OFC1428136871

CAS Number: 1428136-87-1

Unit Molecular Formula: C24H8N4F6SiCu

Unit Molecular Weight: 557.97

KAUST-7

Catalog: OFC1973399073

CAS Number: 1973399-07-3

Unit Molecular Formula: C4H4N2O3F5NiNb

Unit Molecular Weight: 374.68

SIFSIX-1-Cu

Catalog: OFC288297892

CAS Number: 288297-89-2

Unit Molecular Formula: C20H8N4F6SiCu

Unit Molecular Weight: 509.93

MIL-100 (Cr)

Catalog: OFC840523888

CAS Number: 840523-88-8

Unit Molecular Formula: C18O215FCr3

Unit Molecular Weight: 647.16

MIL-101 (Cr)

Catalog: OFC869288095

CAS Number: 869288-09-5

Unit Molecular Formula: C24O165FCr3

Unit Molecular Weight: 719.23

Fluorinated MOFs: Material Solutions that Push the Limits!

• Enhanced hydrophobicity.
• Unique pore structure.
• Improved thermal stability.
• Tailored gas affinity.
• Multifunctionality.
• Environmentally friendly.

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Fluorinated MOFs Synthesis and Functionalization

Common Synthesis Methods

Solvothermal method

The solvothermal method is the most widely used method for the synthesis of fluorinated MOF. The method involves dissolving the metal salt and fluorinated organic ligand in a high-boiling polar solvent (e.g., DMF, DEF, or DMSO) at elevated temperatures (120-200 °C) and high pressures for 12-72 hours.

Advantage:

• Production of high-quality single crystals with controlled morphology and crystallinity.
• Structural diversity is achieved by adjusting the solvent (e.g., hydrophilic solvents enhance stability).

Hydrothermal

Hydrothermal synthesis replaces organic solvents with water, in line with green chemistry principles. The reaction occurs at >100°C and >1 atm, typically resulting in MOFs with enhanced hydrolytic stability.

Advantages:

• Environmentally friendly, avoiding the use of toxic organic solvents.
• Suitable for lanthanide-based MOFs (e.g., Eu³⁺/Tb³⁺-MOF with fluorinated carboxylate ligands).

Mechanochemical methods

Mechanochemical methods involve grinding solid precursors (metal oxides/halides and fluorinated ligands) at room temperature, usually with minimal solvents (liquid assisted grinding, LAG).

Advantages:

• Fast (minutes to hours), solvent-free, and scalable.
• Compatible with insoluble precursors (e.g., ZrF₄ for fluorinating UiO-66).

Post-Synthesis Modification (PSM)

Ligand exchange

Ligand exchange replaces the original ligand in the presynthesized MOF with a fluorinated analog while retaining the framework.

Strategy:

• Solvent-assisted exchange: soak the MOF in a fluorinated ligand solution (e.g., convert MIL-101(Cr) to MIL-101-NH2 by nitration and reduction).
• Gas-phase fluorination: Expose MOF to HF or SF₄ gas to introduce fluorine atoms (e.g., treatment of UiO-66-F with HF).

Fluorination Strategies

• Direct fluorination: Addition of fluorinated ligands during synthesis (e.g., perfluoroterephthalic acid for NU-1000).
• Surface fluorination: Grafting fluorosilanes (e.g., (heptadecafluoro-1,1,2,2-tetrahydrodecyl)triethoxysilane) after synthesis to enhance hydrophobicity.
• Fluorination of inorganic nodes: Replacement of μ3-OH groups in metal clusters with fluorine (e.g., Fe-F-Fe bridge in DNL-9(Fe)).

Structural Tunability and Customization

Pore engineering

• Ligand fluorination: Tuning of ligand length and fluorine substitution (e.g., TKL-104-107 MOF for C₂H₆/C₂H₄ separation).
• Defect introduction: Creation of mesopores by partial ligand removal (e.g., Zr-fcu-MOF with graded porosity).
• Interpenetration: Stacking of fluorinated frameworks (e.g., PCN-61-F with interwoven network for Xe/Kr separation).

Functional group customization

• Acidic/basic sites: Introduction of -CF₃ (electron-withdrawing) or -NH₂ (electron-donating) groups to tailor catalytic activity.
• Example: UiO-66-NH₂-F is used for photocatalytic CO₂ reduction.
• Chiral Fluorination: Use of fluorinated cyclodextrins to create enantioselective MOFs for drug delivery.

Common Synthesis Methods

Post-Synthesis Modification (PSM)

Structural Tunability and Customization

Looking for Specialized F-MOF Customization Services?

By combining fluorination strategies with advanced synthesis and modification techniques, F-MOF can be customized for next-generation applications in the energy, environmental, and biomedical sectors.

Explore Alfa Chemistry's capabilities:

R&D Capabilities

Analytical Capabilities

Production Capabilities

Custom Synthesis Service

Applications of Fluorinated MOFs

Gas Storage and Separation

• CO₂ capture and storage
• Selective gas separation (H₂, CH₄, N₂, O₂, etc.)
• Industrial gas purification

Catalysis

• Heterogeneous catalysis for organic synthesis
• Fluorinated MOFs as catalytic supports
• Photocatalysis and electrocatalysis applications

Energy Storage and Conversion

• Proton conductivity and fuel cells
• MOF-based batteries and supercapacitors

Sensing and Detection

• Chemical and biological sensing
• Fluorescence-based detection for pollutants and toxic gases

Drug Delivery and Biomedical Applications

• Biocompatible fluorinated MOFs for targeted drug delivery
• Controlled release of pharmaceuticals

Water Treatment and Environmental Applications

• Heavy metal ion adsorption and removal
• Organic pollutant degradation
• Hydrophobic MOFs for oil-water separation

Curious About Our Success Stories?

The following case studies demonstrate how our products have led to significant technological breakthroughs and economic benefits in real-world applications.

Case 1: Fluorinated MOFs for CO₂ capture at a research institution

Customer Background: A materials chemistry research team at a leading university is working to develop highly efficient CO₂ capture materials to address industrial carbon emissions.

Product Purchased: F-MIL-101(Cr)

Application Scenario: The research team purchased F-MIL-101(Cr) to conduct CO₂ adsorption experiments and evaluate its performance under different pressure and temperature conditions. The results showed that the fluorination modification significantly enhanced the CO₂ selectivity and stability of the MOFs, especially in high humidity environments.

Customer feedback: The research team recognized the high specific surface area and excellent water stability of the MOFs and plans to further explore their application in industrial carbon capture systems.

What Our Customers Say

Dr. Michael S., a materials research lab in California, USA

"Alfa Chemistry's fluorinated MOF demonstrated superior performance in our gas adsorption studies by showing exceptional adsorption capacity and structural stability, which makes it ideal for extreme environment experimentation. We received professional customer service support throughout, which addressed every one of our technical inquiries."

Prof. James L., Environmental Catalysis Specialist

"The MIL-101(Cr)-F (Catalog: The MIL-101(Cr)-F (Catalog: OFC869288095) that we bought demonstrated excellent performance in catalytic applications. The catalyst retains stable structure when exposed to acid, while its water resistance enhances significantly through surface fluorination modification. The modified catalyst displays more than 30% higher catalytic performance than the non-fluorinated variant, which qualifies it as an optimal choice for exhaust gas treatment reactions."

Dr. Robert K., an environmental science institute in the UK

"Alfa Chemistry was selected by the lab as their MOF material provider after comparing multiple suppliers because their fluorinated MOFs demonstrate superior water resistance, which makes them ideal for gas separation research in moist conditions. Very satisfied with this purchasing experience!"

Dr. William T., drug delivery researcher

"We recently tested Alfa Chemistry's NH2-MIL-101 (Cr)-F (Catalog: OFC1414869956) in a drug carrier study and its high specific surface area and good biocompatibility made it an excellent drug carrier. Fluorination modification effectively improves drug loading efficiency and prolongs release time, making it very suitable for controlled release systems."

What Our Customers Ask

What are the advantages of Fluorinated MOFs over conventional MOFs?

The addition of fluorine atoms to MOFs results in enhanced chemical stability and improved resistance to heat and moisture. Their structure remains intact in moist conditions along with enhanced selectivity and longer lifespan during gas adsorption, separation and catalysis.

How stable are these MOFs? Do they degrade in water or acid-base environments?

Fluorinated MOFs demonstrate improved resistance to water and chemicals because of fluorine incorporation and remain stable in neutral as well as mildly acidic and basic environments. The stability of MOFs varies based on their structure and the specific application environment so users should review product technical data or seek our professional advice before use.

What are the specific applications of fluorinated MOFs in gas adsorption and separation?

Fluorinated MOFs demonstrate exceptional performance for storing and separating gases like CO2, CH2, and H2. Their high aerophilicity along with low polarity makes them ideal for these processes. Their distinct pore structure enhances selectivity performance which positions them as exceptional choices for industrial decarbonization applications alongside air purification and hydrogen storage processes.

Can fluorinated MOFs be used for catalysis?

Yes, fluorinated MOFs demonstrate essential performance in catalytic reactions particularly in the domains of photocatalysis as well as organic conversion reactions and electrocatalysis. Fluorine atoms adjust MOFs electronic properties and improve catalyst performance while extending catalyst durability and stability.

Can the fluorinated MOFs you offer be customized?

Yes, we deliver fluorinated MOFs tailored to customer specifications which encompass various metal centers, customized ligand structures and controlled pore dimensions. Our technical team will provide you with the best material solution for your special needs if you contact us.

Are your fluorinated MOFs suitable for industrial scale applications?

Our product lineup includes fluorinated MOFs available for laboratory research and industrial production scale-up on an as-needed basis. Our batch customization service guarantees consistent material quality while fulfilling large-scale production needs.

*You can get professional answers by reaching out to our technical team if you have additional questions.

Related Resources

¹⁹Fluorine NMR

¹⁹F Coupling Constants Table

¹⁹F NMR Chemical Shift Table