NH2-MIL-101 (Cr)

Application: 1) Gas (such as carbon dioxide) and pollutant adsorption

• Catalog: OFC1414869956
• CAS: 1414869-95-6
• Category: Fluorinated Metal-organic Frameworks (MOFs)

• Unit Molecular Formula: C24N3O15FCr3
• Unit Molecular Weight: 745.25
• Coordination Metal: Cr
• Linkers: 2-Aminoterephthalic acid
• Particle Size: 100-200 nm, 500-800 nm
• Appearance: Grey-green powder
• Storage: 1) Keep sealed in dry and cool condition; 2) It is recommended to activate for 3 hours at 150 degree in vacuum.
• Stability: 1) NH2-MIL-101(Cr) is stable in air and acqeous solutions (PH 1-12); 2)Thermal stability, thermal decomposition temperature above 300 ° C
• Pore Size: Aperture: 1.2-1.6 nm;; Pore size: 2.9-3.4 nm
• Pore Volume: ~2.0 cm3/g
• Surface Area: BET Specific surface: 2000 m2/g

• Coordination Metal: Cr
• Linkers: 2-Aminoterephthalic acid

Case Study

NH2-MIL-101(Cr) for Preparation of Silver-Impregnated NH2-MIL

Eom H. H, et al. Separation and Purification Technology, 2025, 364, 132360.

Silver impregnated NH2-MIL-101(Cr) (Ag@NH2-MIL-101(Cr)) has proven to be an effective electrode material for iodide removal and electrochemical regeneration, enabling sustainable adsorption-desorption cycles.
The synthesis involves the dispersion of NH2-MIL-101(Cr) in n-hexane, followed by impregnation with AgNO₃ and subsequent reduction using NaBH₄ to obtain Ag@NH2-MIL-101(Cr). The incorporation of silver enhances the electrochemical performance, allowing for efficient capture and release of iodide through controlled redox reactions. This makes Ag@NH2-MIL-101(Cr) a promising material for water treatment applications, particularly in the selective removal of iodide from contaminated environments.

NH2-MIL-101(Cr) as a Versatile Host for In Situ Synthesis of Silver Nanoparticle-Embedded Adsorbents

Zhang Q, et al. Separation and Purification Technology, 2025, 360, 131015.

NH2-MIL-101(Cr) serves as a robust metal-organic framework (MOF) for the in situ synthesis of silver nanoparticle (AgNP)-embedded composite adsorbents. Through a controlled chemical modification process, NH2-MIL-101(Cr) undergoes hydroxymethylation in a formaldehyde-ethanol-water system, yielding MIL-101(Cr)-NH-CH2OH.
Synthesis of MIL-101(Cr)-NH-CH2OH: A total of 1.0 g of MIL-101-NH2 was added to 100 mL of a mixed solution of formaldehyde, ethanol, and water (volume ratio 5:20:25) and stirred at 60°C for 120 min. The solid product was then centrifuged, separated, washed multiple times with ethanol, and vacuum-dried at 80°C for 12 h to obtain MIL-101(Cr)-NH-CH2OH.
Synthesis of Ag@MIL-101(Cr)-NH-CH2OH: A biphasic solvent method employing anhydrous n-hexane as a hydrophobic solvent was utilized to facilitate the diffusion of silver precursors into the pores of MIL-101(Cr)-NH-CH2OH. First, 0.1 g of MIL-101(Cr)-NH-CH2OH was uniformly dispersed in 15 mL of anhydrous n-hexane and stirred magnetically. Subsequently, a specific volume of Ag(NH₃)2OH solution was added dropwise under continuous stirring. After stirring at 40°C for 2 h, the supernatant was removed, and the resulting solid was vacuum-dried at 80°C for 12 h to obtain x%Ag@MIL-101(Cr)-NH-CH2OH (x = 2, 4, 6, 8, or 10), where x represents the weight percentage of silver incorporated into MIL-101(Cr)-NH-CH2OH.

NH2-MIL-101(Cr) as a High-Performance Adsorbent for Pharmaceutical Pollutant Removal

Mohmmad A, et al. Ecotoxicology and Environmental Safety, 2024, 278, 116333.

NH2-MIL-101(Cr) has emerged as a highly effective adsorbent for the removal of pharmaceutically active compounds from aqueous environments. Characterized by its high porosity, large specific surface area, and unsaturated metal sites, this metal-organic framework (MOF) exhibits strong adsorption capabilities for a range of pharmaceutical pollutants, including naproxen (697.75 mg/g), diclofenac (704.99 mg/g), and sulfamethoxazole (725.51 mg/g). Molecular dynamics simulations confirm its efficiency in capturing drug molecules through strong host-guest interactions, making it a promising alternative to conventional wastewater treatment methods.

NH2-MIL-101(Cr) as an Efficient Chiral Selector for Enantioseparation of Racemic 1-Phenylethanol

Xing Y, et al. Separation and Purification Technology, 2025, 355(B), 129804.

NH2-MIL-101(Cr) has demonstrated exceptional potential as an enantioselective material for chiral separation, particularly in immobilizing bovine serum albumin (BSA) to enhance separation efficiency. Compared to adsorption and crosslinking methods, the direct bonding of BSA onto NH2-MIL-101(Cr) resulted in the highest BSA loading (437.6 mg g⁻¹), enabling complete chiral resolution of racemic 1-phenylethanol within 14 seconds. The strong binding affinity of NH2-MIL-101(Cr) ⊂ BSA to R-1-phenylethanol, achieving 100% enantiomeric excess with batch additions, highlights its superior selectivity. Molecular docking studies revealed that hydrogen bonding, hydrophobic interactions, and π-π interactions play a crucial role in chiral discrimination, with hydrogen bonding being the dominant factor. Additionally, NH2-MIL-101(Cr) ⊂ BSA exhibited excellent stability and reusability, making it a promising candidate for sustainable chiral separation applications.

NH2-MIL-101 (Cr) as a Functional Material for Electrochemical Immunosensors in SLFN11 Detection

Kanagavalli P, et al. International Journal of Biological Macromolecules, 2025, 285, 138174.

NH2-MIL-101 (Cr) has demonstrated significant potential in electrochemical biosensing applications, particularly for the detection of Schlafen 11 (SLFN11), a biomarker relevant to cancer diagnostics. In a recent study, a composite of NH2-MIL-101 (Cr) and graphene oxide (GO) was engineered to fabricate a high-performance electrochemical immunosensor. The composite underwent electrochemical reduction to form rGO/MIL-101-NH2, enhancing its electrochemical stability and signal response. The amine-functionalized MOF served as a robust immobilization platform for SLFN11-specific antibodies via glutaraldehyde cross-linking, enabling a highly sensitive and selective detection mechanism. The optimized sensor achieved an impressive detection limit of 8.9 pg/mL, demonstrating its suitability for early-stage cancer diagnostics.