Fluorination and Fluoroalkylation Reactions Development

Very few fields in chemistry have shown such a considerable interest as organofluorine chemistry. Because fluorine is the most electronegative element in the periodic table, and the introduction of the incorporation of fluorine or a fluoroalkyl group into a molecule can result in greatly perturbed properties. The deep understanding of fluorine effects has led to organic fluorochemicals becoming a hot spot in various research fields such as medical and agricultural chemistry and materials science. For these reasons, chemical reactions to introduce fluorine and fluoroalkyl group into small organic molecules have been actively investigated for many years by specialists in the field of fluorine chemistry.

Alfa Chemistry has decades of experience on organofluorine chemistry and has accumulated a great deal of reactions experience by studying hundreds and thousands of organic fluorochemicals. Based on this, we can provide development service for various fluorination and fluoroalkylation reactions.

Meet Our Services

Alfa Chemistry aims to design and optimize the fluorination and fluoroalkylation reactions required by our customers to accelerate their different scientific research and commercial application purposes by precisely changing the reaction parameters.

Based on the types of fluorine transfer, we can provide design and optimization services for following reactions:

Electrophilic fluorination and fluoroalkylation reactions

• Fluorination reactions
• Trifluoromethylation reactions
• Difluoromethylation reactions
• Trifluoromethylthiolation reactions
• Monofluoromethylation reactions
• Perfluoroalkylation reactions

Nucleophilic fluorination and fluoroalkylation reactions

• Fluorination reactions
• Trifluoromethylation reactions
• Difluoromethylation reactions
• Trifluoromethylthiolation reactions
• Trifluoromethoxylation reactions
• Perfluoroalkylation reactions

Radical fluorination and fluoroalkylation reactions

• Trifluoromethylation reactions
• Difluoromethylation reactions
• Trifluoromethylthiolation reactions
• Trifluoromethoxylation reactions
• Carbene perfluoroalkylation reactions

Based on the types of substrates, we can provide design and optimization services for following reactions:

• Fluorination and fluoroalkylation of alkenes
• Fluorination and fluoroalkylation of alkynes
• Fluorination and fluoroalkylation of aryl
• Fluorination and fluoroalkylation of carbonyls
• Fluorination and fluoroalkylation of alcohols
• etc.

• Fluorination and fluoroalkylation of amines
• Fluorination and fluoroalkylation of ethers
• Fluorination and fluoroalkylation of heterocycles
• Fluorination and fluoroalkylation of organohalides
• Fluorination and fluoroalkylation of carboxilic acids and derivatives

Main Service Contents

At Alfa Chemistry, in the process of fluorination and fluoroalkylation reactions development service, the following aspects are involved:

• Fluorination and fluoroalkylation reagents selection
• Reaction conditions design and optimization (The reaction conditions include reaction temperature, reaction time, concentration, pH, pressure, catalyst, solvent and many others.)
• Reaction validation and amplification
• …

Our Advantages

Years of experience

Leading in organofluorine chemistry, we have 30 years of proven expertise in API development.

Reliable results

Our experienced experts and latest technology and instruments make your project a success with reliable results.

High quality service

We provide one-to-one service to answer your questions at any time and give feedback project progress timely.

Breakthrough technologies

Our innovative spirit and extraordinary creativity enable us to apply innovative solutions to your API development.

Order Process