Fluorinated APIs Development - Organofluorine / Alfa Chemistry

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Fluorinated APIs Development

Fluorine atom has a unique combination of electronic and physical properties. When it is incorporated into the active pharmaceutical ingredients (API), fluorine atoms, or fluoro-containing groups can change the key characteristics of the API molecule, such as the ability to dissolve in fats and other non-polar solvents, the ability to bind to proteins, the acidity and alkalinity and molecular configuration, etc., and further affecting the biological activity, metabolic stability, bioavailability and toxicity of the active molecule. Therefore, pharmaceutical chemists are increasingly adopting fluorine modification strategies in drug discovery and the strategies have been rapidly developing in recent years. 15 to 20 percent of drugs on the market contain at least one fluorine atom in their structure, and nearly one-third of the blockbuster drugs are fluorinated compounds.

Fluorinated APIs Development

However, the successful integration of fluorine into complex API requires a unique level of expertise, and precise and demanding operating conditions which has greatly limited the development of fluorinated API. Alfa Chemistry has extensive experience in fluorochemistry in the pharmaceutical industry, providing high quality fluorinated API development services for researchers in the pharmaceutical industry.

Meet Our Services

Alfa Chemistry is a leading company in organic fluorine chemistry, focusing on the research and development of organic fluorine related technologies, and the design, synthesis and production of organic fluorine products. With such a strong scientific foundation and cGMP facilities, we offer a full range of services for the fluorinated API development, including:

Early development solutions - route scouting
Process development and optimization
Process validation, process scale-up, and tech transfers
Analysis method development, validation and stability study
Second-generation process development
API solubility enhancement

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Core Strengths and Technologies

It is well known that the fluorinated API development requires a high degree of expertise, and that work with fluorine can be dangerous and requires mastery of a number of hazardous processes. Therefore, to better carry out the above services, Alfa Chemistry has mastered and accumulated a large number of direct technologies (fluorination technology and general organic reactions) and indirect technologies (hazardous processes) for the fluorinated API development.