Fluorination and Fluoroalkylation Reagents Development

The incorporation of a fluorine atom into a compound has a significant electronic consequence and can greatly change the physicochemical properties of compound, then producing remarkable changes in efficacy. Thus, fluorinated compounds have gained great popularity and attention in the preparation of pharmaceuticals, agrochemicals and materials. However, natural products containing at least one fluorine atom are virtually nonexistent, albeit with occasional occurrence ^[1]. Most organofluorine compounds used in academia and industry have been synthesized by fluorination and fluoroalkylation reagents. It can be said that fluorination and fluoroalkylation reagents play an important role in organofluorine chemistry and organofluorine chemicals. Although many fluorination and fluoroalkylation reagents have been developed and applied at present, there is still a great development demand. The development of new fluorination and fluoroalkylation reagents will greatly promote the progress and development of organofluorine chemistry and related fields.

Alfa Chemistry is committed to the progress of organofluorine technology and the development of new fluorination and fluoroalkylation reagents. Our reagent research platform has the world's advanced level of technology and equipment, which can provide customers with the required products in the shortest time.

Meet Our Services

Alfa Chemistry can assist customers in the development of a wide range of fluorination and fluoroalkylation reagents, including but not limited to:

Fluorination reagents

• Nucleophilic fluorination reagents
• Deoxyfluorination reagents
• Electrophilic fluorination reagents

Difluoromethylation reagents

• Nucleophilic difluoromethylation reagents
• Electrophilic difluoromethylation reagents
• Radical difluoromethylation reagents

Trifluoromethylation reagents

• Electrophilic trifluoromethylation reagents
• Nucleophilic trifluoromethylation reagents
• Radical trifluoromethylation reagents

Trifluoromethylthiolation reagents

• Electrophilic trifluoromethylthiolation reagents
• Nucleophilic trifluoromethylthiolation reagents
• Radical trifluoromethylthiolation reagents

Trifluoromethoxylating reagents

• Nucleophilic trifluoromethoxylation reagents
• Radical trifluoromethoxylation reagents

Fluorinated carbene (difluorocarbene) reagents

• Fluoromethyl diazo and hydrazone reagents
• Difluorocarbene reagents

Other fluorination reagents

• Monofluoromethylation reagents
• Perfluoroalkylation reagents
• Others

Alfa Chemistry's services provide customers with new fluorination and fluoroalkylation reagents, while enabling these reagents as good as possible with the following characteristics:

• These fluorination and fluoroalkylation reagents can enable the introduction of various fluorine and fluorine-containing groups and do so cost-effectively with multiple levels of selectivity under mild reaction conditions and tolerate a wide range of functionalities within the substrate.
• These fluorination and fluoroalkylation reagents have convenient synthesis in an economical manner and are stable in air and moisture.

Our Advantages

Years of experience

Leading in organofluorine chemistry, we have 30 years of proven expertise in API development.

Reliable results

Our experienced experts and latest technology and instruments make your project a success with reliable results.

High quality service

We provide one-to-one service to answer your questions at any time and give feedback project progress timely.

Breakthrough technologies

Our innovative spirit and extraordinary creativity enable us to apply innovative solutions to your API development.

Order Process

While advances in the technology for the direct introduction of fluorine and fluorine-containing groups into complex organic compounds has significantly advanced in recent years, there are still plenty of opportunities for the development of novel reagents. At Alfa Chemistry, we are actively pursuing such activities and welcome inquiries in this area.

Reference

1. Qing F. L., et al. A fruitful decade of organofluorine chemistry: new reagents and reactions[J]. CCS Chemistry, 2022, 4(8): 2518-2549.