Fluorination and Fluoroalkylation Reagents

Fluorination Agents

Difluoromethylation Agents

Trifluoromethylation Agents

Trifluoromethylthiolation Agents

Perfluoroalkylation Agents

Other Fluorinated Group Introducing Agents

Introduction

Fluorination and fluoroalkylation reagents can introduce fluorine atoms or fluorine-containing substituents into organic molecules, so they are widely used in the synthesis of fluorine-containing compounds. Organic molecules often exhibit unique physical, chemical and biological properties after introducing fluorine atoms or difluoromethyl, trifluoromethyl, trifluoromethylthio, perfluoroalkyl and other fluorine-containing substituents through fluorination and fluoroalkylation reagents, such as molecular lipophilicity, metabolic stability, antioxidant activity, cell membrane penetration, binding ability to target proteins and bioavailability of molecules. This makes fluorine-containing compounds become a kind of potential bioactive molecules with great application value. Therefore, fluorination and fluoroalkylation reagents have become a research hotspot for organic chemists, and a variety of fluorination and fluoroalkylation reagents have been developed so far, which are widely used in the fields of organic synthesis.

Classification

According to the introduced fluorine-containing groups, fluorination and fluoroalkylation reagents can be mainly divided into fluorinating agents, difluoromethylating agents, trifluoromethylating agents, trifluoromethylthiolating agents and perfluoroalkylating agents.

• Fluorinating agents. Fluorinating agents can introduce fluorine atoms into the molecules. They mainly include HF, KF, NaF, CsF, FCIO₃, CsF, XeF₂, N-fluoropyridinium salts, N-F triethylamine, N-fluorobisbenzenesulfonimide, etc.
• Difluoromethylating agents. Difluoromethylating agents can directly introduce difluoromethyl into the molecules. They mainly include tetramethylsilane (TMS), PhXCF₂H, BrCF₂PO(OEt)₂, difluoromethanesulfonyl chloride, difluoromethyl benzothiazole alum, sodium difluoromethanesulfonyl, brominated difluoromethyl triphenylphosphine, etc.
• Trifluoromethylating agents. Trifluoromethylating agents can directly introduce trifluoromethyl into the molecules. They mainly include CuCF₃, Me₃SiCF₃, CF₃I, CF₃SO₂Na, etc.
• Trifluoromethylthiolating agents. Trifluoromethylthiolating agents can directly introduce trifluoromethylthio into the molecules. They mainly include AgSCF₃, CuSCF₃, trifluoromethylthio tetraalkylammonium (NR₄)SCF₃, N-trifluoromethylthiodiimide reagent, N-trifluoromethylthiobisbenzenesulfonimide reagent, etc.
• Perfluoroalkylating agents. Perfluoroalkylating agents can directly introduce perfluoroalkyl into organic molecules. They mainly include Ruppert-Prakash agents, perfluoroalkyl organometallic agents, perfluoroalkylphenyl iodotrifluoromethanesulfonates (FITS agents), etc.

Applications

Fluorination and fluoroalkylation reagents are common chemical substances, which are widely used in organic synthesis. Fluorinated and fluoroalkylation reagents can be used to directly introduce fluorine atoms or fluorine-containing substituents into organic molecules to synthesize fluorine-containing compounds, which are widely used in the fields of medicine, materials and pesticides. Fluorination and fluoroalkylation reagents can also be used to catalyze organic reactions, promote the progress of the reaction, and improve the yield and selectivity of the reaction. In addition, fluorination and fluoroalkylation reagents can also be used to synthesize ligands and work with catalysts to promote the efficient synthesis of fluorine-containing compounds.

Alfa Chemistry can offer various fluorination and fluoroalkylation reagents, including fluorinating agents, difluoromethylating agents, trifluoromethylating agents, trifluoromethylthiolating agents, perfluoroalkylating agents and other fluorinated group introducing agents. You can click on our product list for a detailed view. If you do not find the product you want, we also offer product customization according to customer's detailed requirements. Please contact us, if you are in need of assistance.