Pharmaceuticals

Introduction

Pharmaceuticals are essential and play an important role in modern medicine. In recent years, organic fluorine chemistry has developed rapidly, and fluorinated pharmaceuticals have been continuously approved and marketed. About 15-20% of new pharmaceuticals launched each year are organic fluorides. The lipophilicity of organic fluorides can improve the cell membrane permeability of pharmaceuticals, thereby improving the bioavailability of pharmaceuticals. At the same time, the strong stability of the C-F bond also enhances the metabolic stability of the pharmaceuticals. With the expansion of the global population and the aggravation of the aging trend, the demand for pharmaceuticals has become increasingly strong, and the position of organic fluorides in pharmaceuticals will become more and more important, and the application will be more extensive.

Representative Examples Of Organic Fluorides In Pharmaceuticals

Due to the strong physiological activity and long action time of organic fluorides, they are widely used in central nervous system pharmaceuticals, antineoplastic pharmaceuticals, antimicrobial pharmaceuticals, anesthetics, anti-inflammatory analgesics and so on. Some representative examples are as follows. Fluphenazine is a fluorinated phenothiazine compound and belongs to the central nervous system pharmaceuticals. It is commonly used in chronic schizophrenia, and can also relieve symptoms such as emotional apathy and behavioral withdrawal. 5-Fluorouracil is a fluorinated pyrimidine compound and belongs to antineoplastic pharmaceuticals, which is commonly used clinically for colon cancer, rectal cancer, gastric cancer, breast cancer, ovarian cancer, skin cancer, liver cancer, bladder cancer, etc. Flucloxacillin is a fluorinated phenyl isoxazole compound, which is belongs to antimicrobial pharmaceuticals and is mainly used for various peripheral infections caused by staphylococcus. Halothane is a trifluoromethylated alkane compound, which is currently the most commonly used inhaled general anesthetic, and it is used in more than 70% of surgeries. Flurbiprofen is a fluorinated arylpropionic acid compound and belongs to the anti-inflammatory analgesics, which is mainly used for rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, etc. It can also be used for soft tissue diseases and mild to moderate pain.

Advantages Of Organic Fluorides In Pharmaceuticals

Compared with non-fluorinated compounds, organic fluorides as pharmaceuticals have the following advantages.

• High bioavailability. Fluorine atoms can improve the lipophilicity of pharmaceutical molecules, enhance the cell membrane permeability of pharmaceuticals and form hydrophobic interactions with specific sites of target proteins. Therefore, compared with non-fluorinated pharmaceuticals, organic fluorides as pharmaceuticals have better biopermeability and better targeting selectivity, and their bioavailability is greatly improved.
• Good metabolic stability. The carbon-fluorine bond is the strongest chemical bond known in organic chemistry. It is not only short, but also difficult to be polarized. Besides, it has strong stability and the carbon-fluorine bond cannot be broken in the way of breaking the carbon-hydrogen bond. Therefore, organic fluorides as pharmaceuticals have good metabolic stability and can act in the body for a long time.

The organic fluorides produced by Alfa Chemistry have a promising future in pharmaceuticals. We will offer the most suitable organic fluorides according to customer's detailed requirements. At the same time, we also offer product customization. Alfa Chemistry provides you with the most professional services and the most favorable prices to buy organic fluorides. Please don't hesitate to contact us.