Aromatic Fluorocarbons

Aromatic Fluorocarbons

Introduction

Aromatic fluorocarbons refer to a series of aromatic compounds with one or several fluorine atoms directly connected to the aromatic ring skeleton. They have many excellent properties due to the presence of fluorine, such as lipophilicity and metabolic stability. Aromatic fluorocarbons are widely used as fluorinated building blocks, which can introduce fluorine atoms or fluorine-containing groups into organic compounds to synthesize new fluorine-containing physiologically active substances. In recent years, the research and development of aromatic fluorocarbons is very active, and they are widely used in pharmaceuticals, pesticides and dyes.

Applications

Aromatic fluorocarbons have relatively stable chemical properties and are mainly used in the synthesis of pharmaceuticals, pesticides and dye molecules.

• Pharmaceuticals. As important fluorinated building blocks, aromatic fluorocarbons are widely used in the synthesis of pharmaceuticals, where fluorine substitution can improve pharmaceutical efficacy and target selectivity by affecting pKa, hydrophobic interaction, lipophilicity, or the superposition of these properties. At present, a series of fluorine-containing pharmaceuticals with high curative effect and less toxic have been synthesized through aromatic fluorocarbons, which have many varieties and different uses. For example, 2,4-dichlorofluorobenzene can be used to synthesize anti-infective fluoroquinolones such as ciprofloxacin, ofloxacin, norfloxacin, etc. Trifluorotoluene is used in the synthesis of appetite suppressant pharmaceutical fenfluramine. 4-Bromo-2-fluoroaniline is used in the synthesis of the anti-inflammatory pharmaceutical ibuprofen. 4-Fluorobenzoyl chloride is used to synthesize cardiovascular and cerebrovascular pharmaceuticals such as fluvastatin sodium.

• Pesticides. In the field of pesticides, aromatic fluorocarbons building blocks are widely used in the synthesis of herbicides, insecticides, and fungicides. For example, trifluralin, an excellent herbicide, can be synthesized from p-chlorobenzotrifluoride. Diflubenzuron, a specific low toxicity insecticide, can be synthesized from 1-bromo-2,6-difluorobenzene or 2,6-difluorobenzamide. Fluoropyrimidine, a widely used fungicide, can be synthesized from fluorobenzene.

• Dyes. Aromatic fluorocarbons building blocks can also introduce fluorine atoms or fluorine-containing groups into dye molecules to improve their light resistance and produce brightly colored dyes. For example, fluoropyrimidines are widely used in the synthesis of reactive dye molecules.

Alfa Chemistry can offer various aromatic fluorocarbons building blocks. You can click on our product list for a detailed view. At the same time, we also offer product customization according to customer's detailed requirements. If you are interested in our products, please feel free to contact us. We will be happy to provide you with support and services.