Organic Synthesis

Introduction

Organic synthesis is one of the most important disciplines in the field of chemistry, which plays a very important role in the development of social civilization and people's daily life. Firstly, organic synthesis can prepare natural organic substances to make up for the shortage of natural resources. Secondly, it can synthesize organic substances with specific functions that do not exist in nature, changing people's living habits and improving the quality of people's life. Thirdly, it can partially modify the structure of natural organic substances to make their performance more perfect. Organic fluorides are indispensable and important compounds in organic synthesis, possessing excellent physical and chemical properties such as strong polarity, good inertness, high solubility, strong stability and physiological activity. They widely participate in a series of organic synthesis reactions, and can synthesize organic compounds with specific structures and functions, which greatly promotes the development of organic synthesis.

Applications Of Organic Fluorides In Organic Synthesis

Organic fluorides have good reactivity and are significant means to synthesize various important natural products and their derivatives, organic chemical raw materials or fine chemicals in organic synthesis.

• Synthesis of natural products and their derivatives. Fluorinated natural products and their derivatives are mostly artificially synthesized, and organic fluorides are important raw material for their synthesis. For example, In 2013, Rao et al. developed the synthesis method of irinotecan, which is a derivative of natural product camptothecin. They started from the easily available and inexpensive organic fluoride 3-fluorobenzaldehyde, passing through the 2-amino-5-hydroxypropiophenone intermediate and finally successfully synthesized irinotecan^[1].

Fig.1 Synthesis of irinotecan

• Synthesis of organic chemical raw materials. Many important chemical raw materials can be synthesized through organic fluorides. For example, tetrafluoroethylene or 2,2,3,3-tetrafluoro-4-methoxy-4-oxobutanoic acid can further synthesize the important fluorine chemical raw material methyl 2,2,3,3-tetrafluoro-3- methoxypropionate. It is mainly used as a key intermediate for the production of perfluorocarboxylic acid resin and an important raw material for the production of perfluorinated or partially fluorinated vinyl ether.
• Synthesis of fine chemicals. Organic fluorides are also used in the synthesis of fine chemicals. For example, hexafluoropropylene oxide is used to synthesize hexafluoroisopropanol, which can further prepare fine chemicals such as fluorinated surfactants and fluorinated emulsifiers. Difluoroethanol is used to synthesized 1,1-difluoroethyl-2,2-difluoroethyl ether, which is used as a cleaning agent for stainless steel plates. Hexafluoro-2-butyne is used to synthesized cis-1,1,1,4,4,4-hexafluoro-2-butene, which is used as a new generation of green and environmentally friendly foaming agent, refrigerant, and fire extinguishing agent.

Alfa Chemistry can provide a range of organic fluorides for organic synthesis, which can synthesize compounds with specific structures and functions such as natural products and their derivatives, organic chemical raw materials or fine chemicals. We will offer the most suitable organic fluorides according to customer's detailed requirements. At the same time, we also offer product customization. Alfa Chemistry provides you with the most professional services and the most favorable prices to buy organic fluorides. Please don't hesitate to contact us.

Reference

1. Rao, A. V. R.; et al. Scalable synthetic route to 2-amino-5-hydroxypropiophenone: Efficient formal synthesis of irinotecan. Synthetic Commun. 2013, 43: 1661-1667.