Pimasertib

Description: Pimasertib / AS703026 / SAR245509 / MSC1936369B selectively binds to and inhibits the activity of MEK1/2, preventing the activation of MEK1/2-dependent effector proteins and transcription factors, which may result in the inhibition of growth factor-mediated cell signaling and tumor cell proliferation.

• Catalog: OFC1236699925
• CAS: 1236699-92-5
• Category: Fluorinated APIs
• Synonyms: AS703026
• Purity: >98%

• IUPAC Name: N-[(2S)-2,3-dihydroxypropyl]-3-(2-fluoro-4-iodoanilino)pyridine-4-carboxamide
• InChI: InChI=1S/C15H15FIN3O3/c16-12-5-9(17)1-2-13(12)20-14-7-18-4-3-11(14)15(23)19-6-10(22)8-21/h1-5,7,10,20-22H,6,8H2,(H,19,23)/t10-/m0/s1
• InChI Key: VIUAUNHCRHHYNE-JTQLQIEISA-N
• Isomeric SMILES: C1=CC(=C(C=C1I)F)NC2=C(C=CN=C2)C(=O)NC[C@@H](CO)O

• Molecular Formula: C15H15FIN3O3
• Molecular Weight: 431.2
• Appearance: White to off-white solid powder

• XLogP3-AA: 1.7
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 6
• Exact Mass: 431.01422 g/mol
• Monoisotopic Mass: 431.01422 g/mol
• Topological Polar Surface Area: 94.5Ų
• Heavy Atom Count: 23
• Formal Charge: 0
• Complexity: 391