Foretinib

Description: Foretinib / XL880 / GSK1363089, is an orally bioavailable small molecule with potential antineoplastic activity. MET/VEGFR2 inhibitor GSK1363089 binds to and selectively inhibits hepatocyte growth factor (HGF) receptor c-MET and vascular endothelial growth factor receptor 2 (VEGFR2), which may result in the inhibition of tumor angiogenesis, tumor cell proliferation and metastasis.

• Catalog: OFC849217647
• CAS: 849217-64-7
• Category: Fluorinated APIs
• Synonyms: XL880
• Purity: >98%

• IUPAC Name: 1-N'-[3-fluoro-4-[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxyphenyl]-1-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
• InChI: InChI=1S/C34H34F2N4O6/c1-43-30-20-25-27(21-31(30)45-16-2-13-40-14-17-44-18-15-40)37-12-9-28(25)46-29-8-7-24(19-26(29)36)39-33(42)34(10-11-34)32(41)38-23-5-3-22(35)4-6-23/h3-9,12,19-21H,2,10-11,13-18H2,1H3,(H,38,41)(H,39,42)
• InChI Key: CXQHYVUVSFXTMY-UHFFFAOYSA-N
• Isomeric SMILES: COC1=CC2=C(C=CN=C2C=C1OCCCN3CCOCC3)OC4=C(C=C(C=C4)NC(=O)C5(CC5)C(=O)NC6=CC=C(C=C6)F)F
• EC Number: 629-893-0

• Molecular Formula: C34H34F2N4O6
• Molecular Weight: 632.65
• Appearance: White to off-white solid powder

• XLogP3-AA: 5.5
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 10
• Rotatable Bond Count: 12
• Exact Mass: 632.24464114 g/mol
• Monoisotopic Mass: 632.24464114 g/mol
• Topological Polar Surface Area: 111Ų
• Heavy Atom Count: 46
• Formal Charge: 0
• Complexity: 1010