4-Ethyl-N-(3-((4-methylpiperazin-1-yl)methyl)-5-(trifluoromethyl)phenyl)-3-(pyrazolo[1,5-a]pyrimidin-6-ylethynyl)benzamide

• Catalog: OFC1429617902
• CAS: 1429617-90-2
• Category: Fluorinated Amides
• Purity: 97%
• MDL Number: MFCD30185014

• Molecular Formula: C30H29F3N6O
• Molecular Weight: 546.59
• Molar Refractivity: 154.91

• Bioavailability Score: 0.55
• Egan: 0.0
• Ghose: None
• Lipinski: 1.0
• Muegge: 0.0
• Veber: 0.0
• Consensus LogP: 4.63
• MLogP: 4.09
• SILICOS-IT: 4.9
• WLogP: 4.84
• XLogP3: 4.51
• iLogP: 4.79
• BBB Permeant: Yes
• CYP1A2 Inhibitor: No
• CYP2C19 Inhibitor: Yes
• CYP2C9 Inhibitor: Yes
• CYP2D6 Inhibitor: Yes
• CYP3A4 Inhibitor: No
• GI Absorption: High
• LogKp: -6.43 cm/s
• P-gp Substrate: Yes
• Fraction Csp3: 0.3

• GHS Pictogram: GHS07
• Hazard Statements: H302-H315-H319-H335
• Precautionary Statements: P261-P305+P351+P338