BMS-777607

Description: BMS-777607 is a Met-related inhibitor for c-Met, Axl, Ron and Tyro3 with IC50 of 3.9 nM, 1.1 nM, 1.8 nM and 4.3 nM in cell-free assays, 40-fold more selective for Met-related targets versus Lck, VEGFR-2, and TrkA/B, and more than 500-fold greater selectivity versus all other receptor and non receptor kinases. Phase 1/2.

• Catalog: OFC1025720948
• CAS: 1025720-94-8
• Category: Fluorinated APIs
• Synonyms: N-(4-((2-amino-3-chloropyridin-4-yl)oxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide
• Purity: >98%

• IUPAC Name: N-[4-(2-amino-3-chloropyridin-4-yl)oxy-3-fluorophenyl]-4-ethoxy-1-(4-fluorophenyl)-2-oxopyridine-3-carboxamide
• InChI: InChI=1S/C25H19ClF2N4O4/c1-2-35-19-10-12-32(16-6-3-14(27)4-7-16)25(34)21(19)24(33)31-15-5-8-18(17(28)13-15)36-20-9-11-30-23(29)22(20)26/h3-13H,2H2,1H3,(H2,29,30)(H,31,33)
• InChI Key: VNBRGSXVFBYQNN-UHFFFAOYSA-N
• Isomeric SMILES: CCOC1=C(C(=O)N(C=C1)C2=CC=C(C=C2)F)C(=O)NC3=CC(=C(C=C3)OC4=C(C(=NC=C4)N)Cl)F

• Molecular Formula: C25H19ClF2N4O4
• Molecular Weight: 512.89
• Appearance: White to off-white solid powder

• XLogP3-AA: 4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 7
• Exact Mass: 512.1062891 g/mol
• Monoisotopic Mass: 512.1062891 g/mol
• Topological Polar Surface Area: 107Ų
• Heavy Atom Count: 36
• Formal Charge: 0
• Complexity: 867