SKLB610

Description: SKLB-610 is a multi-target inhibitor of the tyrosine kinases. It is most potent against VEGFR2 and exhibits slightly weaker inhibitor of FGFR2 and PDGFR.

• Catalog: OFC1125780417
• CAS: 1125780-41-7
• Category: Fluorinated APIs
• Purity: >98%

• IUPAC Name: N-methyl-4-[4-[[3-(trifluoromethyl)benzoyl]amino]phenoxy]pyridine-2-carboxamide
• InChI: InChI=1S/C21H16F3N3O3/c1-25-20(29)18-12-17(9-10-26-18)30-16-7-5-15(6-8-16)27-19(28)13-3-2-4-14(11-13)21(22,23)24/h2-12H,1H3,(H,25,29)(H,27,28)
• InChI Key: WACDHHMEVMSODJ-UHFFFAOYSA-N
• Isomeric SMILES: CNC(=O)C1=NC=CC(=C1)OC2=CC=C(C=C2)NC(=O)C3=CC(=CC=C3)C(F)(F)F

• Molecular Formula: C21H16F3N3O3
• Molecular Weight: 415.37
• Appearance: White to off-white solid powder

• XLogP3-AA: 3.7
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 5
• Exact Mass: 415.11437587 g/mol
• Monoisotopic Mass: 415.11437587 g/mol
• Topological Polar Surface Area: 80.3Ų
• Heavy Atom Count: 30
• Formal Charge: 0
• Complexity: 594