ASP5878

Description: ASP5878 is a novel FGFR-selective inhibitor with IC50 values of 0.47, 0.60, 0.74, and 3.5 nmol/L for recombinant FGFR1, 2, 3, and 4, respectively.

• Catalog: OFC1453208666
• CAS: 1453208-66-6
• Category: Fluorinated APIs
• Purity: >98%

• IUPAC Name: 2-[4-[[5-[(2,6-difluoro-3,5-dimethoxyphenyl)methoxy]pyrimidin-2-yl]amino]pyrazol-1-yl]ethanol
• InChI: InChI=1S/C18H19F2N5O4/c1-27-14-5-15(28-2)17(20)13(16(14)19)10-29-12-7-21-18(22-8-12)24-11-6-23-25(9-11)3-4-26/h5-9,26H,3-4,10H2,1-2H3,(H,21,22,24)
• InChI Key: VDZZYOJYLLNBTD-UHFFFAOYSA-N
• Isomeric SMILES: COC1=CC(=C(C(=C1F)COC2=CN=C(N=C2)NC3=CN(N=C3)CCO)F)OC

• Molecular Formula: C18H19F2N5O4
• Molecular Weight: 407.37
• Appearance: White to off-white solid powder

• XLogP3-AA: 1.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 10
• Rotatable Bond Count: 9
• Exact Mass: 407.14051043 g/mol
• Monoisotopic Mass: 407.14051043 g/mol
• Topological Polar Surface Area: 104Ų
• Heavy Atom Count: 29
• Formal Charge: 0
• Complexity: 473