Types of Collagen - Collagen / Alfa Chemistry

Resources

Online Inquiry

Name:

* Email:

Phone:

Quantity:

* Services & Products Interested:

Project Description :

* Verification Code:

Types of Collagen

Collagen is an abundant structural protein in animals. In humans, collagen accounts for one-third of total protein, three-quarters of the dry weight of the skin, and it is the most prevalent component of the extracellular matrix (ECM). Twenty-eight different types of collagen (table 1) ^[1] have been identified in vertebrates that consist of at least 46 different polypeptide chains, and many other proteins contain collagenous structural domains.

Type	Form	Composition	Distribution	Pathology
I	Fibrillar	α1[I]₂α2[I]	Abundant and widespread: dermis, bone, tendon, ligament	OI, Ehlers–Danlos syndrome, osteoporosis
II	Fibrillar	α1[II]₃	Cartilage, vitreous	Osteoarthrosis, chondrodysplasias
III	Fibrillar	α1[III]₃	Skin, blood vessels, intestine	Ehlers-Danlos syndrome, arterial aneurysms
IV	Network	α1[IV]₂α2[IV] α3[IV]α4[IV]α5[IV] α5[IV]₂α6[IV	Basement membranes	Alport syndrome
V	Fibrillar	α1[V]₃ α1[V]₂α2[V] α1[V]α2[V]α3[V]	Widespread: bone, dermis, cornea, placenta	Ehlers-Danlos syndrome
VI	Network	α1[VI]α2[VI] α3[VI] α1[VI]α2[VI] α4[VI]	Widespread: bone, cartilage, cornea, dermis	Bethlem myopathy
VII	Anchoring fibrils	α1[VII]₂α2[VII]	Dermis, bladder	Epidermolysis bullosa acquisita
VIII	Network	α1[VIII]₃ α2[VIII]₃ α1[VIII]₂α2[VIII]	Widespread: dermis, brain, heart, kidney	Fuchs endothelia corneal dystrophy
IX	FACIT	α1[IX]α2[IX]α3[IX]	Cartilage, cornea, vitreous	Osteoarthrosis, multiple epiphyseal dysplasia
X	Network	α1[X]₃	Cartilage	Chondrodysplasia
XI	Fibrillar	α1[XI]α2[XI]α3[XI]	Cartilage, intervertebral disc	Chondrodysplasia, osteoarthrosis
XII	FACIT	α1[XII]₃	Dermis, tendon	—
XIII	MACIT	—	Endothelial cells, dermis, eye, heart	—
XIV	FACIT	α1[XIV]₃	Widespread: bone, dermis, cartilage	—
XV	MULTIPLEXIN	—	Capillaries, testis, kidney, heart	—
XVI	FACIT	—	Dermis, kidney	—
XVII	MACIT	α1[XVII]₃	Hemidesmosomes in epithelia	Generalized atrophic epidermolysis bullosa
XVIII	MULTIPLEXIN	—	Basement membrane, liver	Knobloch syndrome
XIX	FACIT	—	Basement membrane	—
XX	FACIT	—	Cornea (chick)	—
XXI	FACIT	—	Stomach, kidney	—
XXII	FACIT	—	Tissue junctions	—
XXIII	MACIT	—	Heart, retina	—
XXIV	Fibrillar	—	Bone, cornea	—
XXV	MACIT	—	Brain, heart, testis	—
XXVI	FACIT	—	Testis, ovary	—
XXVII	Fibrillar	—	Cartilage	—
XXVIII		—	Dermis, sciatic nerve	—

These different types of collagen carry out specific functions in different tissues and have different supramolecular organization patterns. Some molecules are homotrimers, while others are heterotrimers with two or three distinguishable chain types ^[2].

Fig. 1 Illustration of some of the biological forms of the collagen triple-helix domains

Alfa Chemistry is a professional synthetic biology company that manufactures recombinant human collagen and other high-value proteins at scale. For high quality products and more information, please feel free to contact us.

References

Shoulders, M. D., & Raines, R. T. Collagen Structure and Stability. Annual Review of Biochemistry, 2009, 78(1), 929–958.
Brodsky, B., & Persikov, A. V. Molecular Structure of the Collagen Triple Helix. Advances in Protein Chemistry, 2005, 301–339.

Possibilities are unlimited with Alfa Chemistry. Let's discuss your idea.

Contact Us

Please kindly note that our products and services are for research use only.