Recombinant Human Collagen-Phosphorylcholine Hydrogels in Regenerative Medicine Application

A range of hydrogels, membranes, webs and other structures made from biomimetic materials have now been developed as tissue models and scaffolds or templates for regenerative medicine. In regenerative medicine applications, the interface between the implant and the host is now recognized as a key factor in guiding the repair and regeneration of the target tissue or organ. Mirazul ^[1] et al. prepared a new kind of recombinant human collagen-phosphorylcholine hydrogel and evaluated the use of ultrahigh-speed femtosecond lasers developed for ophthalmic surgery to profile recombinant human collagen type III and 2-methacryloyloxyethyl phosphorylcholine (RHCIII–MPC) hydrogel for surgical grafting.

Study showed that these RHCIII–MPC hydrogels could stimulate regeneration while repelling blood vessel intrusion into the implant in a rabbit alkali burn cornea model of severe pathology. RCIII-MPC gel, as a suitable implant material, could be cut with high precision using a femtosecond laser. And it was robust enough to maintain its integrity during laser cutting, which is important for grafting applications that do not require suturing.

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