Introduction
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Data SheetSoy peptide is an active small molecule peptide which is extracted from soy isolate protein by enzymatic hydrolysis process. And it is a rich source of high-quality protein containing all the essential amino acids found in animal proteins without cholesterol and with less saturated fat.
Fig. 1 Soy peptide powder
The popularity of soy foods or products has been rising over the last decades, particularly after the Food and Drug Administration approved the food health claim linking soy protein to the reduction of the risk for coronary heart disease in 1999.
Extraction Process
Soy peptide can be extracted from soybean isolate protein by bio-complex enzyme digestion, and the detail process is as below.
Fig. 2 Soy bioactive peptide production flow
Properties and Application
The functional and nutritional properties of soybeans are attributed to biomolecules and other functional groups in
forms and quantities that confer certain desirable traits. In terms of functional properties, soy proteins have
shown properties such as foaming, adhesive and emulsifying qualities. Nutritionally, soy proteins are ‘complete
proteins’ for human health and growth because they are highly digestible, supply all the essential amino
acids. Beyond basic nutrition, certain soy proteins and products thereof are known to possess drug-like or
nutraceutical properties which are of immense value in food, pharmaceutical and cosmetic products.
Bioactive peptides from soybean have been shown to exhibit a variety of functional properties, including
immunomodulatory, antioxidant, and hypocholesterolemic effects, etc. Soy peptide has beneficial effects on
diabetes, obesity, and serum lipids, etc.
- Immunomodulatory
Soy peptide has been confirmed that it’s a kind of immunomodulatory peptide and can boost immune cell functions, for example, natural killer cell activity or cytokine regulation[1]. An immunostimulating glutamine-rich peptide was purified from a soybean protein fraction digested with Peptidase R produced by Rhizopus oryzae (Ro-digest) by a combination of SP-Sepharose column chromatography and reversed-phase high-performance liquid chromatography. And the result indicate that the glutamine-rich region of the soybean glycinin G4 subunit stimulates the cellular immune system in mouse spleen cell cultures[2].
- Antioxidant
Soy based antioxidative peptides have been reported in a number of studies. Lunasin is a novel peptide identified in soybean and other seeds. As an anti-oxidant, lunasin was shown to inhibit 2,20-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt radical scavenger, reactive oxygen species production, and the secretion of pro-inflammatory cytokines (Tumor Necrosis Factor-α and IL-6) in mouse RAW 264.7 macrophages[3].
- Anti-Cancer
Bioactive peptides with anticancer properties have been widely reported. The soy peptides showed a dose-dependent growth inhibition of around colon cancer (73%), liver cancer (70%) and lung cancer (68%) cell lines. The bioactive peptides were between 5-10 kDa in size and were also resistant to the action of gastrointestinal enzymes. This together with the anticancer properties shows the potential of soybean peptides to control the proliferation of colon, liver and lung cancer cell lines[3].
Fig. 3 Anticancer mechanisms of Anticancer peptides (ACP)
- Prevent Cardiovascular and Cerebrovascular Disease
Hyperlipidemia, hyperglycemia and hypertension are three mainly risk factors for cardiovascular and cerebrovascular disease.
Fig. 4 Cardiovascular and cerebrovascular disease diagram
Many soy peptides have been identified to lower cholesterol and triglycerides, and to suppress fat synthesis and storage in different experimental systems[5].
Over the years, research has shown that soybeans contain several biomolecules including proteins and peptides which possess antiobesity, anti-fatigue and antidiabetic properties. Particularly, aglycin has been reported as a natural bioactive peptide found in plant albumins of pea seeds such as soybean. This 37 residue peptide is able to resist proteolytic attack during transit in the gastrointestinal system of mammals.
In the body, blood pressure and fluid balance are controlled by the renin-angiotensin system where-converting-I enzymes (ACE) play a key role. ACE causes restriction of blood vessels, leading to hypertension. Shimakage et al. have reported soy peptides are good candidates for the generation of ACE-inhibitory compounds. Also, the action of the bacterial neutral protease (PROTIN SD-NY10) was important for the generation of ACE-inhibitory bioactive properties[4].
Alfa Chemistry supplies soy peptide with molecular weight less than 1000Dal. Which can be used in food, beverage, liquid dairy products, medicine and health care products. You can access to technical data for detail information. Please feel free to contact us if you have any questions.
References
- Wang W.; De Mejia, E.G. A new frontier in soy bioactive peptides that may prevent age-related chronic diseases. Comp. Rev. Food Sci. Food Saf. 2005, 4, 63–78.
- Shintaro EGUSA, Hajime OTANI. Characterization of a cellular immunostimulating peptide from a soybean protein fraction digested with Peptidase R. J Nutr Sci Vitaminol, 55, 428-433,2009.
- Lule, V.K., Garg, S., Pophaly, S.D., et al. Potential health benefits of lunasin: A multifaceted soy-derived bioactive peptide. J. Food Sci. 2015, 80, R485-R494.
- Dominic Agyei. Bioactive Proteins and Peptides from Soybeans. Recent Patents on Food, Nutrition & Agriculture, 2015, 7, 100-107.
- Cynthia Chatterjee , Stephen Gleddie, and Chao-Wu Xiao. Soybean Bioactive Peptides and Their Functional Properties. Nutrients 2018, 10, 1211.
