Oligonucleotides are a class of single- or double-stranded small synthetic nucleic acid polymers. Initially, they were used almost exclusively in laboratory research, being synthesized and used generally as molecular probes to detect complementary DNA or RNA sequences. With ongoing technological advancements, these molecules have become essential tools in modern molecular biology, diagnostics, and drug development. From gene synthesis and sequencing to the development of innovative therapies, they play a crucial role in various applications.
Our Products
Alfa Chemistry is at the cutting edge of oligonucleotide drug and intermediate development. We utilize synthetic biology and liquid phase molecular synthesis technologies to provide our customers with the following high-quality products:
- Oligonucleotide Synthesis Building Blocks
Oligonucleotide synthesis building blocks are the fundamental components used to create oligonucleotides. These building blocks include, but are not limited to, 3'-protected monomers, 5'-DMTr-3'-OH oligomers, 3'-protected oligomers, and 3'-phosphoramidite oligomers. They are synthesized using liquid phase synthesis technology, characterized by a low monomer feed ratio, minimal solvent usage, easy purification, and strong scalability.
- Cyclic Dinucleotides
Cyclic dinucleotides (CDNs) are a class of small, cyclic molecules composed of two nucleotide units joined together by phosphodiester bonds in a ring structure. They play crucial roles as signaling molecules in both prokaryotic and eukaryotic cells. CDNs can trigger the innate immune response in eukaryotic cells through the stimulator of interferon genes (STING) signalling pathway has led to extensive research and development of CDNs as potential immunostimulators and novel molecular adjuvants for induction of systemic and mucosal innate and adaptive immune responses [1].
Choose Alfa Chemistry
Oligonucleotides have become essential tools in the development of modern science, driving advancements in molecular biology, diagnostics, and therapeutic innovation. Alfa Chemistry is proud to support researchers and innovators by providing high-quality oligonucleotide series products. Our commitment to excellence ensures that you have access to the products you need to make groundbreaking discoveries and develop innovative therapies. If you have any need, please feel free to contact us.
Reference
- Yan, H.; Chen, W. The promise and challenges of cyclic dinucleotides as molecular adjuvants for vaccine development. Vaccines. 2021, 9(8): 917.
