Introduction
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Data SheetOyster peptide is a small molecular collagen peptide, it is extracted from fresh oyster or natural dried oyster by special pre-treatment and targeted bio-enzyme digestion technology at low temperature. Oyster peptide contains the trace elements (Zn, Se, etc.), oyster polysaccharides and taurine. It is widely used in food, pharmaceuticals and health care products.
Fig. 1 Oyster peptide
Effects of Oyster peptide
Oyster peptides are not only rich in protein, vitamins, trace elements with appropriate proportion and taurine, but also contain a variety of nutrients that marine organisms are specific. And a large number of clinical data confirm that oyster can improve the level of testosterone in male serum, regulate blood lipid, inhibit platelet aggregation, improve the symptoms of hyperglycemia, improve immunity, protect liver and promote metabolism. Here we mainly main introduce the following three effects:
- Antithrombotic activity
It has been proved that oyster peptides, released in the SID (simulated intestinal digestion) tract, increase the APTT (activated partial thromboplastin time) and TT (thromboplastin time) for human serum clotting. In addition, Lineweaver–Burk plot analysis shows a competitive inhibition effect on thrombin. One novel peptide, LSKEEIEEAKEV, identified from oyster hydrolysates, shows a high affinity to thrombin, displaying similar characteristics to those of bivalirudin and hirudin variant-2 [1].
Fig. 2 Peptide LSKEEIEEAKEV and hirudin variant-2 docking with thrombin at Exosite I. (a and b) The 3D model of
hirudin variant-2 and peptide LSKEEIEEAKEV; (c) the 3D model of peptide LSKEEIEEAKEV docking with thrombin at
Exosite I in the S1 pocket, where the yellow stick structure is the framework of peptide 1 and the ribbon structure
is thrombin
- Antioxidant and anti-inflammatory
Bingjun Qian[2] studied the antioxidant and anti-inflammatory effects of four hydrophobic peptide fractions which obtained from enzyme hydrolysates of oyster soft tissue. The results show that they exhibited the antioxidant capacity based on DPPH (2,2-diphenyl-1-picrylhydrazyl radical) scavenging capacity, FRAP (ferric reducing antioxidant power) and ORAC (oxygen radical absorbance capacity) assay in vitro. In addition, the four peptide fractions also showed anti-inflammatory activities.
- Protective effect on testicular injury and spermatogenesis disorders
Xueyan Zhang[3] studied the mechanism of peptides from oyster on triptolide-induced testis injury in male mice. The results showed that Ops (oyster peptides) significantly improved the sperm count and motility of mice and alleviated the seminiferous tubule injury. Possible mechanism is showed below.
Fig. 3 Possible mechanism underlying the protective effects of oyster peptides intervention on triptolide-induced
testicular damage in mice
Alfa Chemistry supplies oyster peptide with molecular weight less than 1000Dal. which can be used in food, health care, pharmaceuticals industries. You can access to technical data for detail information. Please feel free to contact us if you have any questions.
References
- Hui Chen, Shuzhen Cheng, Fengjiao Fan, et al. Identification and molecular mechanism of antithrombotic peptides from oyster proteins released in simulated gastro-intestinal digestion. Food & Function, 2019.
- Bingjun Qian, Xin Zhao, Ye Yang, Chongchong Tian. Antioxidant and anti-inflammatory peptide fraction from oyster soft tissue by enzymatic hydrolysis. Food Sci Nutr. 2020;8:3947–3956.
- Xueyan Zhang, Zhilan Peng, Huina Zheng, et al. The Potential Protective Effect and Possible Mechanism of Peptides from Oyster (Crassostrea hongkongensis) Hydrolysate on Triptolide-Induced Testis Injury in Male Mice. Mar. Drugs 2021, 19, 566.
