Introduction
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Data SheetMarine fish oligopeptide is a deep processed product of deep-sea type I collagen peptide which is mainly extracted from cod fish skin consisting of 26 amino acids with a molecular weight of 500-1000dalton. Marine fish oligopeptide can be absorbed directly by small intestine, human skin and it has strong nutritional characteristics and wide applications such as in food, health care, pharmaceuticals and cosmetics industries, etc.
Fig. 1 Marine fish oligopeptide
Effects of Marine Fish Oligopeptide
The peptides, which are present in the inactive form within the protein chains, are activated after their hydrolysis using enzymes, including trypsin, proteinases, chymotrypsin, alcalase, and pepsin. Depending on their structures and amino acid sequences, marine fish proteins and peptides exhibit a wide range of biological activities including antioxidant, antimicrobial, anticancer effects and other effects.
- Antioxidant
K.H. Sabeena Farvin, et al.[1] demonstrated that the presence of both antioxidant peptides and free amino acids in the cod oligopeptide significantly contribute to the high oxidative stability of 5% fish oil in water emulsions containing such hydrolysates. Free amino acids with antioxidative properties were present in all fractions, and the total content of free amino acids were higher in the<3 kDa fraction compared to other fractions.
- Antimicrobial
It has been proved that the antimicrobial peptides (AMPs) can be extracted from Atlantic cod mucus[2]. AMPs are a class of small peptides that widely exist in nature and they are an important part of the innate immune system of different organisms. AMPs have a wide range of inhibitory effects against bacteria, fungi, parasites and viruses.
- Anticancer
In recent years, bioactive peptides obtained from the skin gelatin of marine animals have been reported to have anticancer potential due to their antioxidant, antiproliferative, and anti-inflammatory activities. It has been demonstrated that the cod skin oligopeptide inhibited the growth of gastric cancer cells by inducing apoptosis through modulation of the expression of apoptosis-related proteins. These data suggest that the oligopeptide obtained from cod skin could be an interesting source of anticancer peptide and is a promising therapeutic agent for gastric cancer[3].
Applications and Functions
Our marine fish oligopeptide with molecular weight less than 1000Dal (customizable) which is extracted from cod fish can be used in food, health care, and cosmetics industries, etc.
Fig. 2 Main applications of marine fish oligopeptide
The functions of marine fish oligopeptide are showed as below
- Effectively solve the skin and muscle moisture reduction problem, timely supplement the collagen to keep skin young.
- Tightly bind calcium to bone cells, no loss or degradation.
- Keep the cornea moist and transparent, increase the transparency of the eyes.
- Promote the close connection of muscle cells to make them elastic and glossy.
- Regulate the endocrine, protect and enhance the visceral function.
- Combined with immune globulin, increase immunity.
Alfa Chemistry supplies marine fish oligopeptide with molecular weight less than 1000Dal. which can be used in food, health care, and cosmetics industries. You can access to technical data for detail information. Please feel free to contact us if you have any questions.
Reference
- K.H. Sabeena Farvin, Lisa Lystbæk Andersen, Jeanette Otte , et al. Antioxidant activity of Cod (Gadus morhua) protein hydrolysates: Fractionation and Characterisation of peptide fractions. fractions. Food Chemistry, 204, 409-419.
- Bergsson, G., Agerberth, B., Jörnvall, H., Gudmundsson, G. H. Isolation and identification of antimicrobial components from the epidermal mucus of Atlantic cod (Gadus morhua). The FEBS Journal, 2005, 272: 4960–4969.
- Liping Wu, Xiaofei Hu, Liyun Xu & Guoqiang Zhang. Cod Skin Oligopeptide Inhibits Human Gastric Carcinoma Cell Growth by Inducing Apoptosis. Nutrition and Cancer, 2019, 0163-5581.
