NMR Instrument Platform

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Welcome to our nuclear magnetic resonance (NMR) instrument platform, a state-of-the-art facility designed to support cutting-edge research and advanced applications in chemistry, biochemistry, materials science, and medicine. Our platform offers comprehensive NMR services and access to high-resolution instruments, enabling precise molecular characterization and structural analysis.

What is NMR?

NMR is a powerful analytical technique used to determine the structure, dynamics, reaction state, and chemical environment of molecules. NMR exploits the magnetic properties of certain atomic nuclei. When placed in a magnetic field, nuclei of specific isotopes absorb and re-emit electromagnetic radiation at characteristic frequencies. This phenomenon provides detailed information about the molecular structure and interactions.

Fig.1 Liquid-state NMR spectroscopy for complex carbohydrate structural analysis

Principles of NMR

Magnetic Properties of Nuclei - Nuclei with an odd number of protons or neutrons have a nonzero magnetic moment and can be studied by NMR.
Resonance - When placed in a magnetic field, these nuclei resonate at a frequency specific to their environment, known as the Larmor frequency.
Chemical Shift - The resonance frequency of a nucleus depends on its electronic environment, providing a "chemical shift" that helps identify chemical structures.
Spin-Spin Coupling - Interactions between neighboring nuclear spins split NMR signals into multiplets, offering additional structural information.

Capabilities and Instrumentation

Our NMR Instrument Platform is equipped with a variety of high-field and low-field NMR spectrometers, each suited for different types of analyses.

300 MHz NMR Spectrometer

The cornerstone of our platform is the 300 MHz NMR spectrometer. This instrument is ideal for routine analysis and research applications, providing excellent sensitivity and resolution. Its capabilities include:

¹H and ¹³C NMR: These fundamental nuclei are essential for organic and biochemical analysis.
Multinuclear Capabilities: The spectrometer can analyze a wide range of other nuclei, including ¹⁵N, ³¹P, and ¹⁹F, allowing for diverse applications.
Variable Temperature Control: Enables studies of temperature-dependent phenomena in samples.
Advanced Pulse Sequences: Supports a variety of 1D and 2D NMR techniques, including COSY, NOESY, HSQC, and HMBC, which are crucial for detailed structural analysis.
Automation and High Throughput: Equipped with an autosampler for handling multiple samples, enhancing efficiency and productivity.

500 MHz NMR Spectrometer

High sensitivity and resolution, suitable for complex organic molecules and large biomolecules.

Structure elucidation, protein-ligand interactions, and natural product identification.

600 MHz CryoProbe NMR Spectrometer

Enhanced sensitivity with cryogenically cooled probes, ideal for detecting low-concentration samples.

Metabolomics, detailed structural biology studies, and in-depth chemical analysis.

800 MHz NMR Spectrometer

Ultra-high resolution for large biomolecules, such as proteins and nucleic acids.

Advanced structural biology, protein dynamics, and complex mixture analysis.

Our Services Offered

Our platform provides a wide range of NMR services to meet diverse research needs:

Structural Elucidation: Determination of molecular structures through 1D and 2D NMR techniques, including COSY, NOESY, HSQC, and HMBC.
Quantitative NMR (qNMR): Precise quantification of compounds in mixtures, useful for purity assessment and mixture analysis.
Dynamic Studies: Investigation of molecular dynamics and interactions using relaxation time measurements (T1, T2) and diffusion-ordered spectroscopy (DOSY).
Metabolomics: Comprehensive profiling of metabolites in biological samples, supporting biomarker discovery and metabolic pathway analysis.
Solid-State NMR: Analysis of solid materials, including polymers, pharmaceuticals, and catalysts, with techniques such as MAS (Magic Angle Spinning).

Our NMR Instrument Platform is committed to excellence in research and development, providing the tools and expertise necessary to unlock the mysteries of molecular structures and dynamics. For more information about our NMR instrument platform, services, or to discuss potential collaborations, please contact us.