Ginseng, a well-known traditional medicinal herb, has been esteemed for centuries for its myriad health benefits. This revered plant holds high medicinal and cosmetic values due to its potent antioxidant, anti-inflammatory, and anti-aging properties. Not only are ginseng roots celebrated, but its stems and leaves are equally rich in bioactive components that contribute to its efficacy. Recent studies have highlighted that the fermentation of ginseng stem and leaf extracts can further enhance their cosmetic properties, making them a promising ingredient in the skincare industry.
Bioactive Compounds in Ginseng
The therapeutic potential of ginseng is attributed to its rich content of bioactive compounds, including ginsenosides, polysaccharides, phenolics, and flavonoids. Among these, ginsenosides are the primary active components, comprising about 4% of the total ginseng content. These compounds are ubiquitous in all parts of the ginseng plant - roots, stems, leaves, and fruits. Notably, rare ginsenosides are particularly significant due to their potent pharmacological activities.
Ginsenoside CK, for example, has been shown to enhance the activity of antioxidant enzymes in the skin, protect keratin-forming cells and dermal fibroblasts from ultraviolet (UV) damage, and exhibit strong photoprotective effects. Such properties make ginsenoside CK an invaluable component in anti-aging and photoprotective skincare formulations.
Fermentation Enhances Cosmetic Properties
Fermentation is a process that can significantly boost the cosmetic properties of ginseng extracts. By fermenting ginseng stem and leaf extracts, the bioavailability and efficacy of the active compounds are enhanced, resulting in a more potent skincare ingredient. Researchers have conducted extensive studies to evaluate the antioxidant capabilities of fermented ginseng extracts, particularly focusing on their impact on skin cells.
In Vitro Studies on Fermented Ginseng Extracts
In a notable study, researchers used two human cell lines, HaCaT (keratinocytes) and BJ (fibroblasts), to assess the antioxidant effects of unfermented ginseng sap (GS) and fermented ginseng fluid (GF). The results were compelling, demonstrating that GF exhibited a remarkable increase in free radical scavenging activities:
Fig. 1 Ginseng stem and leaf extracts were fermented with five different lactic acid bacteria strains and their antioxidant activities were investigated.
Superoxide anion (O2·−) Scavenging Capacity: Increased by 73.00%
Hydroxyl radical (·OH) Scavenging Capacity: Increased by 94.00%
2,2-diphenyl-1-picrylhydrazyl (DPPH) Scavenging: Increased by 25.00%
These findings highlight the strong free radical scavenging activity of GF against DPPH, ·OH, and O2·− radicals.
Fig. 2 Antioxidant effect of GF.
Protective and Reparative Effects
Further analysis revealed that 0.06% of GF was non-cytotoxic and exhibited both protective and reparative effects on H2O2-treated HaCaT cells. GF significantly increased the viability of these cells, effectively protecting them from oxidative stress-related injury and aiding in the repair of damaged cells. This study provides substantial evidence that the solution produced by fermenting ginseng stem and leaf extract with lactobacilli possesses significant antioxidant activity, making it a valuable component in formulations aimed at slowing down skin aging.
Fig. 3 Effects of GS and GF on the activity of HaCaT/BJ cells treated with H2O2.
The research into fermented ginseng extracts underscores their potential as a powerful ingredient in functional cosmetics. Their ability to eliminate free radicals and prevent and repair oxidative cellular damage positions fermented ginseng as a promising option for anti-aging skincare products. By harnessing the enhanced properties of fermented ginseng stem and leaf extracts, the skincare industry can offer innovative solutions that help protect the skin from environmental stressors and maintain a youthful appearance. Ginseng, with its rich tradition and scientifically proven benefits, continues to be a natural elixir for health and beauty.
Reference
- Optimization of Antioxidant Activity of Compounds Generated during Ginseng Extract Fermentation Supplemented with Lactobacillus. Molecules (2024).
