Specification
Description
The Dpm group has increased stability compared to Trt, enabling selective removal of Mtt groups on the solid phase with dilute TFA without loss of Dpm groups. Furthermore, the Dpm group is removed by treatment with 95% TFA cleavage cocktails. Racemization during carboxyl activation is lower with this derivative than with Fmoc-Cys(Trt)-OH.
Synonyms
Fmoc-Cys(Dpm)-OH, N-α-Fmoc-S-diphenylmethyl-L-cysteine
InChI
1S/C31H27NO4S/c33-30(34)28(20-37-29(21-11-3-1-4-12-21)22-13-5-2-6-14-22)32-31(35)36-19-27-25-17-9-7-15-23(25)24-16-8-10-18-26(24)27/h1-18,27-29H,19-20H2,(H,32,35)(H,33,34)/t28-/m0/s1
InChI Key
IVPLDYIPIHKRET-NDEPHWFRSA-N
Boiling Point
714.3±60.0℃at 760 mmHg
Solubility
Clearly soluble (1 mmole in 2 ml DMF)
Application
Fmoc solid-phase peptide synthesis
Functional Group
Fmoc, thiol
Storage Temperature
15-25℃
Type
Unusual Amino Acids, Analogs of Cysteine and Methionine