Chlorhexidine

• CAS: 55-56-1
• Catalog Number: ACM55561-1
• Category: Main Products
• Molecular Weight: 505.45
• Molecular Formula: C22H30Cl2N10
• Synonyms: 1,1'-Hexamethylenebis(5-(p-chlorophenyl)-biguanid;1,6-bis(5-(p-chlorophenyl)biguandino)hexane; 1,6-bis(p-chlorophenyldiguanido)hexane
• IUPAC Name: (1E)-2-[6-[[amino-[(E)-[amino-(4-chloroanilino)methylidene]amino]methylidene]amino]hexyl]-1-[amino-(4-chloroanilino)methylidene]guanidine
• InChI: InChI=1S/C22H30Cl2N10/c23-15-5-9-17(10-6-15)31-21(27)33-19(25)29-13-3-1-2-4-14-30-20(26)34-22(28)32-18-11-7-16(24)8-12-18/h5-12H,1-4,13-14H2,(H5,25,27,29,31,33)(H5,26,28,30,32,34)
• InChI Key: GHXZTYHSJHQHIJ-UHFFFAOYSA-N
• Melting Point: 134-136 °C (lit.)
• Density: 1.39 g/cm³
• Solubility: Soluble in water (0.08%) at 20 °C
• Appearance: White powder
• Active Content: 95%
• Assay: 0.999
• Complexity: 649
• EC Number: 200-238-7
• Exact Mass: 504.2031964
• Formal Charge: 0
• Hazard Statements: Xi,N
• Heavy Atom Count: 34
• Hydrogen Bond Acceptor Count: 2
• Hydrogen Bond Donor Count: 6
• Isomeric SMILES: C1=CC(=CC=C1N/C(=N/C(=NCCCCCCN=C(/N=C(/NC2=CC=C(C=C2)Cl)\N)N)N)/N)Cl
• MDL Number: MFCD00009673
• Monoisotopic Mass: 504.2031964
• Packaging: 1 kg
• Packing Group: III
• Physical State: Solid
• Rotatable Bond Count: 13
• Safety Description: 26-36/37-60-61
• Stability: Stable. Incompatible with strong oxidizing agents.
• Storage Conditions: Room temperature
• Supplemental Hazard Statements: H315-H319-H334-H335-H410
• Symbol: GHS07,GHS08,GHS09
• Topological Polar Surface Area: 178 Ų
• WGK Germany: 3

Case Study

Chlorhexidine and Synoeca-MP Synergistic Combination for Enhanced Antimicrobial Activity and Tissue Regeneration in Oral Diseases

Ingrid Aquino Reichert Barin, et al. Archives of Oral Biology, 2025, 172, 106177.

Chlorhexidine demonstrates enhanced antimicrobial and biofilm-inhibiting properties when combined with Synoeca-MP, an antimicrobial peptide derived from the class of defense peptides. This synergistic combination has been evaluated for its potential in treating oral diseases, particularly those involving Pseudomonas aeruginosa and Candida albicans. In vitro studies revealed that low concentrations of chlorhexidine and Synoeca-MP effectively inhibited these pathogens, with minimal toxicity to human periodontal ligament cells. The synergistic formulation also exhibited stability in healthy human saliva, although degradation was observed in the presence of periodontal disease.
Further investigations demonstrated that the combination promoted periodontal ligament cell proliferation and migration, indicating regenerative potential for tissue repair. Additionally, this combination inhibited osteoclastogenesis, a critical process in bone resorption, thereby supporting bone homeostasis. Mineralized matrix formation was enhanced in both ligament cells and SaOs-2 osteoblast-like cells, reinforcing the potential of this formulation in promoting bone regeneration.

Custom Q&A

What is the CAS number for Chlorhexidine?

The CAS number for Chlorhexidine is 55-56-1.

What are some synonyms for Chlorhexidine?

Some synonyms for Chlorhexidine include 1,1'-Hexamethylenebis(5-(p-chlorophenyl)-biguanid and 1,6-bis(5-(p-chlorophenyl)biguandino)hexane.

What is the molecular weight of Chlorhexidine?

The molecular weight of Chlorhexidine is 505.45.

What is the molecular formula of Chlorhexidine?

The molecular formula of Chlorhexidine is C22H30Cl2N10.

What is the InChI key for Chlorhexidine?

The InChI key for Chlorhexidine is GHXZTYHSJHQHIJ-UHFFFAOYSA-N.

What is the melting point of Chlorhexidine?

The melting point of Chlorhexidine is 134-136 °C (lit.).

What is the purity of Chlorhexidine?

The purity of Chlorhexidine is 99+%.

What is the density of Chlorhexidine?

The density of Chlorhexidine is 1.39 g/cm³.

What are the typical applications of Chlorhexidine?

Chlorhexidine is commonly used as an antimicrobial agent and preservative.

What is the physical state of Chlorhexidine?

The physical state of Chlorhexidine is a solid in the form of white powder.