XI-011 HCl

• CAS: 59474-01-0
• Catalog Number: ACM59474010-1
• Category: Inhibitors
• Molecular Weight: 316.85
• Molecular Formula: C17H17ClN2S
• Description: XI-011 (NSC146109), a small-molecule inhibitor of MDMX, showed robust anti-proliferation activity against several cervical cancer cell lines. XI-011 promoted apoptosis of cervical cancer cells via stabilizing p53 and activating its transcription activity. Moreover, XI-011 inhibited the growth of xenograft tumor in HeLa tumor-bearing mice, as well as enhanced the cytotoxic activity of cisplatin both in vitro and in vivo.
• Synonyms: XI-011 HCl; XI-011 hydrochloride; XI-011; XI011; XI011; NSC 146109 HCl; NSC146109; NSC146109
• IUPAC Name: Carbamimidothioic acid, (10-methyl-9-anthracenyl)methyl ester, monohydrochloride
• Canonical SMILES: NC(SCC1=C2C=CC=CC2=C(C)C3=CC=CC=C13)=N.[H]Cl
• InChI: InChI=1S/C17H16N2S.ClH/c1-11-12-6-2-4-8-14(12)16(10-20-17(18)19)15-9-5-3-7-13(11)15;/h2-9H,10H2,1H3,(H3,18,19);1H
• InChI Key: VIBMUYOXJUCEMA-UHFFFAOYSA-N
• Solubility: To be determined
• Appearance: Solid powder
• Shelf Life: >2 years if stored properly
• Storage: Dry, dark and at 0-4 °C for short term (days to weeks) or -20 °C for long term (months to years).
• Alternative CAS: 740031-90-7 (free base); 59474-01-0 (HCl)
• Drug Formulation: To be determined
• Elemental Analysis: C, 64.44; H, 5.41; Cl, 11.19; N, 8.84; S, 10.12
• HS Tariff Code: 2934.99.9001
• Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
• Stock Solution Storage: 0-4 °C for short term (days to weeks), or -20 °C for long term (months).