F1063-0967

• CAS: 613225-56-2
• Catalog Number: ACM613225562
• Category: Inhibitors
• Molecular Weight: 484.59
• Molecular Formula: C24H24N2O5S2
• Description: F1063-0967 is a novel inhibitor of dual-specificity phosphatase 26 (DUSP26), inducing apoptosis in IMR-32 cell line.
• Synonyms: F1063-0967; F1063 0967; F10630967; F-10630967; F 10630967
• IUPAC Name: (Z)-2-Hydroxy-4-{6-[5-(4-methyl-benzylidene)-4-oxo-2-thioxo-thiazolidin-3-yl]-hexanoylamino}-benzoic acid
• Canonical SMILES: O=C(O)C1=CC=C(NC(CCCCCN(C/2=O)C(SC2=C/C3=CC=C(C)C=C3)=S)=O)C=C1O
• InChI: InChI=1S/C24H24N2O5S2/c1-15-6-8-16(9-7-15)13-20-22(29)26(24(32)33-20)12-4-2-3-5-21(28)25-17-10-11-18(23(30)31)19(27)14-17/h6-11,13-14,27H,2-5,12H2,1H3,(H,25,28)(H,30,31)/b20-13-
• InChI Key: RNICWTYEMLCCAS-MOSHPQCFSA-N
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Shelf Life: >2 years if stored properly
• Storage: Dry, dark and at 0-4 °C for short term (days to weeks) or -20 °C for long term (months to years).
• Biological Target: F1063-0967 is a Dual-specificity phosphatase 26 (DUSP26) inhibitor with an IC50 of 11.62 μM.
• Drug Formulation: This drug may be formulated in DMSO
• Elemental Analysis: C, 59.49; H, 4.99; N, 5.78; O, 16.51; S, 13.23
• Exact Mass: 484.1127
• HS Tariff Code: 2934.99.9001
• In Vitro Activity: The inhibitory activity of F1063-0967 against DUSP26 is higher than that of NCS87877 (IC50 value: 16.67±2.89μM), but lower than that of ethyl-3, 4-dephostatin (IC50 value: 6.8±0.41μM). MTT assay results revealed that F1063-0967 can induce apoptosis in IMR-32 cell line with an IC50 value of 4.13μM.; Reference: Biomed Pharmacother. 2017 May;89:376-385. https://pubmed.ncbi.nlm.nih.gov/28249240/
• In Vivo Activity: TBD
• Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
• Stock Solution Storage: 0-4 °C for short term (days to weeks), or -20 °C for long term (months).