Ulodesine

• CAS: 548486-59-5
• Catalog Number: ACM548486595
• Category: Inhibitors
• Molecular Weight: 264.28
• Molecular Formula: C12H16N4O3
• Description: Ulodesine, also known as BCX4208, is a purine nucleoside phosphorylase (PNP) inhibitor in development as a once-daily oral, chronic treatment for gout. Ulodesine is currently being developed by Biocryst. Ulodesine acts upstream of xanthine oxidase in the purine metabolism pathway to reduce the production of serum uric acid (sUA). Ulodesine has an IC(50) of 0.5 nM to PNP. BCX-4208 is currently undergoing early clinical investigation in psoriasis and gout.
• Synonyms: BCX4208, BCX 4208, BCX-4208, Ulodesine, DADMe-immucillin H
• IUPAC Name: 7-(((3R,4R)-3-hydroxy-4-(hydroxymethyl)pyrrolidin-1-yl)methyl)-3H-pyrrolo[3,2-d]pyrimidin-4(5H)-one
• Canonical SMILES: O=C1C(NC=C2CN3C[C@H](O)[C@@H](CO)C3)=C2N=CN1
• InChI: InChI=1S/C12H16N4O3/c17-5-8-3-16(4-9(8)18)2-7-1-13-11-10(7)14-6-15-12(11)19/h1,6,8-9,13,17-18H,2-5H2,(H,14,15,19)/t8-,9+/m1/s1
• InChI Key: AFNHHLILYQEHKK-BDAKNGLRSA-N
• Solubility: Soluble in DMSO, not in water
• Appearance: Solid powder
• Shelf Life: >5 years if stored properly
• Storage: Dry, dark and at 0-4 °C for short term (days to weeks) or -20 °C for long term (months to years).
• Biological Target: Ulodesine, also known as BCX4208, is a purine nucleoside phosphorylase (PNP) inhibitor.
• Drug Formulation: This drug may be formulated in DMSO
• Elemental Analysis: C, 54.54; H, 6.10; N, 21.20; O, 18.16
• Exact Mass: 264.12224
• HS Tariff Code: 2934.99.9001
• In Vitro Activity: TBD
• In Vivo Activity: TBD
• Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
• Stock Solution Storage: 0-4 °C for short term (days to weeks), or -20 °C for long term (months).