TH257

• CAS: 2244678-29-1
• Catalog Number: ACM2244678291
• Category: Inhibitors
• Molecular Weight: 422.54
• Molecular Formula: C24H26N2O3S
• Description: TH257 is a Potent and selective allosteric LIMK 1/2 inhibitor.
• Synonyms: TH257; TH-257; TH 257
• IUPAC Name: N-Butyl-4-[(phenylamino)sulfonyl]-N-(phenylmethyl)benzamide
• Canonical SMILES: O=C(N(CCCC)CC1=CC=CC=C1)C2=CC=C(S(=O)(NC3=CC=CC=C3)=O)C=C2
• InChI: InChI=1S/C24H26N2O3S/c1-2-3-18-26(19-20-10-6-4-7-11-20)24(27)21-14-16-23(17-15-21)30(28,29)25-22-12-8-5-9-13-22/h4-17,25H,2-3,18-19H2,1H3
• InChI Key: VNCIWNGCMAKKEO-UHFFFAOYSA-N
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Shelf Life: >3 years if stored properly
• Storage: Dry, dark and at 0-4 °C for short term (days to weeks) or -20 °C for long term (months to years).
• Biological Target: TH-257 is a potent inhibitor of LIMK1 and LIMK2 with IC50 values of 84 nM and 39 nM for LIMK1 and LIMK2, respectively, and it can be used as a chemical probe for LIMK1 and LIMK2.
• Drug Formulation: This drug may be formulated in DMSO
• Elemental Analysis: C, 68.22; H, 6.20; N, 6.63; O, 11.36; S, 7.59
• Exact Mass: 422.1664
• HS Tariff Code: 2934.99.9001
• In Vitro Activity: TBD
• In Vivo Activity: TBD
• Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
• Stock Solution Storage: 0-4 °C for short term (days to weeks), or -20 °C for long term (months).