SKF89976A

• CAS: 85375-15-1
• Catalog Number: ACM85375151-1
• Category: Inhibitors
• Molecular Weight: 335.45
• Molecular Formula: C22H25NO2
• Description: SKF89976A is a potent GABA uptake inhibitor, which is selective for GAT-1 (IC50 values are 0.13, 550, 944 and 7210 μM for hGAT-1, rGAT-2, hGAT-3 and hBGT-1 respectively). SKF89976A inhibits transport current competitively (Ki = 7 μM) and transmitter-gated current non-competitively (Ki = 0.03 nM). It is able to pass the blood-brain barrier after systemic administration and is active in vivo.
• Synonyms: SKF89976A; SKF 89976A; SKF-89976A
• IUPAC Name: 1-(4,4-diphenylbut-3-en-1-yl)piperidine-3-carboxylic acid
• Canonical SMILES: O=C(C1CN(CC/C=C(C2=CC=CC=C2)/C3=CC=CC=C3)CCC1)O
• InChI: InChI=1S/C22H25NO2/c24-22(25)20-13-7-15-23(17-20)16-8-14-21(18-9-3-1-4-10-18)19-11-5-2-6-12-19/h1-6,9-12,14,20H,7-8,13,15-17H2,(H,24,25)
• InChI Key: TXQKSMSLZVKQBI-UHFFFAOYSA-N
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Shelf Life: >2 years if stored properly
• Storage: Dry, dark and at 0-4 °C for short term (days to weeks) or -20 °C for long term (months to years).
• Alternative CAS: 85375-15-1 ( free base); 85375-85-5 (HCl)
• Drug Formulation: This drug may be formulated in DMSO
• Elemental Analysis: C, 78.77; H, 7.51; N, 4.18; O, 9.54
• Exact Mass: 335.1885
• HS Tariff Code: 2934.99.9001
• Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
• Stock Solution Storage: 0-4 °C for short term (days to weeks), or -20 °C for long term (months).