CMPD101

• CAS: 865608-11-3
• Catalog Number: ACM865608113
• Category: Inhibitors
• Molecular Weight: 466.47
• Molecular Formula: C24H21F3N6O
• Description: CMPD101 is a novel, potent and selective G-protein coupled receptor kinase 2 and 3 (GRK2/GRK3) inhibitor (IC50 values are 35 and 32 nM at GRK2 and GRK3 respectively). CMPD101 exhibits selectivity for GRK2/3 over GRK1/5 and reduces DAMGO-induced desensitization and internalization of μ-opioid receptors. CMPD101 has been shown to potentiate phosphatidylinositol 4,5-bisphosphate (PIP2) depletion and slow agonist-induced desensitization of protease-activated receptor 2 (PAR2).
• Synonyms: CMPD101; CMPD 101; CMPD-101; Takeda101; Takeda-101; Takeda 101
• IUPAC Name: 3-[[[4-Methyl-5-(4-pyridinyl)-4H-1,2,4-triazol-3-yl]methyl]amino]-N-[[2-(trifluoromethyl)phenyl]methyl]benzamide
• Canonical SMILES: O=C(NCC1=CC=CC=C1C(F)(F)F)C2=CC=CC(NCC3=NN=C(C4=CC=NC=C4)N3C)=C2
• InChI: InChI=1S/C24H21F3N6O/c1-33-21(31-32-22(33)16-9-11-28-12-10-16)15-29-19-7-4-6-17(13-19)23(34)30-14-18-5-2-3-8-20(18)24(25,26)27/h2-13,29H,14-15H2,1H3,(H,30,34)
• InChI Key: WFOVEDJTASPCIR-UHFFFAOYSA-N
• Solubility: Soluble in DMSO, not in water
• Appearance: Solid powder
• Shelf Life: >2 years if stored properly
• Storage: Dry, dark and at 0-4 °C for short term (days to weeks) or -20 °C for long term (months to years).
• Biological Target: CMPD101 is a small-molecule inhibitor of GRK2/3 with IC50 of 18 nM and 5.4 nM, respectively.
• Drug Formulation: This drug may be formulated in DMSO
• Elemental Analysis: C, 61.80; H, 4.54; F, 12.22; N, 18.02; O, 3.43
• Exact Mass: 466.17289
• HS Tariff Code: 2934.99.9001
• In Vitro Activity: In conclusion, CMPD101 inhibits adrenergic, neurogenic, and non-adrenergic smooth muscle contractions in the human prostate.
• In Vivo Activity: TBD
• Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
• Stock Solution Storage: 0-4 °C for short term (days to weeks), or -20 °C for long term (months).