Nolatrexed dihydrochloride

• CAS: 152946-68-4
• Catalog Number: ACM152946684
• Category: Inhibitors
• Molecular Weight: 357.26
• Molecular Formula: C₁₄H₁₂N₄OS?2(HCl)
• Description: Nolatrexed dihydrochloride (AG 337) is a non-competitive lipophilic inhibitor of thymidylate synthase, interacts at the folate cofactor binding site of the enzyme, with a Ki of 11 nM for human thymidylate synthase. Nolatrexed dihydrochloride (AG 337) induces cell cycle arrest in S phase of cancer cells. Anti-cancer activity.
• Synonyms: Nolatrexed dihydrochloride
• Canonical SMILES: [H]Cl.O=C1N=C(N)NC2=C1C(SC3=CC=NC=C3)=C(C)C=C2.[H]Cl
• Density: g/cm³
• Appearance: Tan Solid
• Storage: -20°C, sealed storage, away from moisture*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture).
• Shipping: Can be shipped at room temperature, where not in use may vary.