Cycloguanil hydrochloride

• CAS: 152-53-4
• Catalog Number: ACM152534
• Category: Inhibitors
• Molecular Weight: 288.18
• Molecular Formula: C₁₁H₁₅Cl₂N₅
• Description: Cycloguanil hydrochloride, the active metabolite of Proguanil, acts on malaria schizonts in erythrocytes and hepatocytes.
• Synonyms: 1-(4-Chlorophenyl)-1,6-dihydro-6,6-dimethyl-1,3,5-triazine-2,4-diamine Hydrochloride; BN 2410; Chloroguanide Triazine Hydrochloride; Cycloguanil Hydrochloride; NSC 3074
• IUPAC Name: 1-(4-chlorophenyl)-6,6-dimethyl-1,3,5-triazine-2,4-diamine hydrochloride
• Canonical SMILES: CC1(N=C(N=C(N1C2=CC=C(C=C2)Cl)N)N)C.Cl
• InChI Key: MOUAPRKJJUXEIE-UHFFFAOYSA-N
• Boiling Point: 400.7ºC at 760mmHg
• Melting Point: 210-215ºC
• Flash Point: 196.1ºC
• Appearance: White Solid
• Storage: 4°C, sealed storage, away from moisture*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture).
• Exact Mass: 287.07000
• H-Bond Acceptor: 5
• H-Bond Donor: 3
• Shipping: Can be shipped at room temperature, where not in use may vary.

Synthetic Use

Upstream Synthesis Route 1

• 4022-81-5
• 67-64-1

• 152-53-4

Reference: [1] Synthetic Communications, 2002, vol. 32, # 14, p. 2089 - 2100

Upstream Synthesis Route 2

• 106-47-8
• 127099-85-8
• 67-64-1

• 152-53-4

Reference: [1] Journal of Medicinal Chemistry, 2000, vol. 43, # 14, p. 2738 - 2744
[2] Bioorganic and Medicinal Chemistry Letters, 2009, vol. 19, # 19, p. 5644 - 5647

Upstream Synthesis Route 3

• 127099-85-8
• 106-47-8
• 67-64-1

• 152-53-4

Reference: [1] Journal of Medicinal Chemistry, 1984, vol. 27, # 2, p. 129 - 143

Upstream Synthesis Route 4

• 127099-85-8
• 106-47-8
• 67-64-1

• 152-53-4

Reference: [1]Journal of Medicinal Chemistry,1984,vol. 27,p. 129 - 143

Upstream Synthesis Route 5

• 106-47-8
• 127099-85-8
• 67-64-1

• 152-53-4

Reference: [1]Journal of Medicinal Chemistry,2000,vol. 43,p. 2738 - 2744
[2]Bioorganic and Medicinal Chemistry Letters,2009,vol. 19,p. 5644 - 5647

Downstream Synthesis Route 1

• 152-53-4

• 5405-65-2

Reference: [1]Journal of Heterocyclic Chemistry,1993,vol. 30,p. 849 - 854
[2]Bioorganic and Medicinal Chemistry Letters,2009,vol. 19,p. 5644 - 5647

* For details of the synthesis route, please refer to the original source to ensure accuracy.