NCGC00244536

• CAS: 2003260-55-5
• Catalog Number: ACM2003260555
• Category: Inhibitors
• Molecular Weight: 382.46
• Molecular Formula: C25H22N2O2
• Description: KDM4B-IN-B3, also know as NCGC00244536, is a novel KDM4 inhibitor. KDM4B-IN-B3 inhibits the in vivo growth of tumors derived from PC3 cells and ex vivo human PCa explants. Histone lysine demethylase KDM4/JMJD2s are overexpressed in many human tumors including prostate cancer (PCa).
• Synonyms: KDM4B-IN-B3; KDM4B IN B3; KDM4BINB3; NCGC00244536; NCGC-00244536; NCGC 00244536
• IUPAC Name: 3-(8-Hydroxyquinolin-6-yl)-N-(3-phenylpropyl)benzamide
• Canonical SMILES: O=C(NCCCC1=CC=CC=C1)C2=CC=CC(C3=CC(O)=C4N=CC=CC4=C3)=C2
• InChI: InChI=1S/C25H22N2O2/c28-23-17-22(16-20-12-6-13-26-24(20)23)19-10-4-11-21(15-19)25(29)27-14-5-9-18-7-2-1-3-8-18/h1-4,6-8,10-13,15-17,28H,5,9,14H2,(H,27,29)
• InChI Key: NYKBXXGHEMXSBB-UHFFFAOYSA-N
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Shelf Life: >2 years if stored properly
• Storage: Dry, dark and at 0-4 °C for short term (days to weeks) or -20 °C for long term (months to years).
• Biological Target: NCGC00244536 is a potent KDM4B inhibitor with an IC50 of 10 nM.
• Drug Formulation: This drug may be formulated in DMSO
• Elemental Analysis: C, 78.51; H, 5.80; N, 7.32; O, 8.37
• Exact Mass: 382.1681
• HS Tariff Code: 2934.99.9001
• In Vitro Activity: This study tested the effect of these compounds on the growth of LNCaP cells (Fig. S1A) and selected NCGC00247751 (A1), NCGC00244536 (B3), and NCGC00247743 (I9), which inhibited LNCaP cell growth with IC50s in the μM range (Fig. 1A). These inhibitors suppressed the catalytic activity of KDM4B effectively and among them B3 was the most potent, with an IC50 of ca. 10 nM (Fig. 1B).; Reference: Chem Biol. 2015 Sep 17;22(9):1185-96. https://pubmed.ncbi.nlm.nih.gov/26364928/
• In Vivo Activity: TBD
• Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
• Stock Solution Storage: 0-4 °C for short term (days to weeks), or -20 °C for long term (months).