L-Homoarginine hydrochloride

• CAS: 1483-01-8
• Catalog Number: ACM1483018-1
• Category: Amino Acids
• Molecular Weight: 224.69
• Molecular Formula: H2NC(=NH)NH(CH2)4CH(NH2)CO2H · HCl
• Synonyms: (S)-2-Amino-6-guanidinohexanoic acid hydrochloride
• Canonical SMILES: Cl[H].N[C@@H](CCCCNC(N)=N)C(O)=O
• InChI: 1S/C7H16N4O2.ClH/c8-5(6(12)13)3-1-2-4-11-7(9)10;/h5H,1-4,8H2,(H,12,13)(H4,9,10,11);1H/t5-;/m0./s1
• InChI Key: YMKBVNVCKUYUDM-JEDNCBNOSA-N
• Melting Point: 213-215 ℃(lit.)
• Solubility: H2O: soluble
• Application: L-Homoarginine may be used to create non-natural proteins for studies of post-translational protein modifications. Arginine residues are often located at the active centers of proteins and enzymes. Replacing these arginines with homoarginine can elucidate protein function and structural requirements. L-Homoarginine is used to study the mechanisms of nitric oxide production by cells via nitric oxide synthase(s). L-Homoarginine is used as a selective mammalian alkaline phosphatase isoenzyme inhibitor. The substitution of homoarginine for arginine or lysine renders proteins resistant to proteolysis by trypsin.
• Assay: ≥98% (TLC)
• Beilstein: 4016621
• Biochem Physiol Actions: Homoarginine is an inhibitor of tissue nonspecific alkaline phosphatase (TNALP). It is also an inhibitor of cellular transport of arginine by a sodium-independent high affinity y+ transporter.
• Color: white to off-white
• EC Number: 216-045-6
• Form: powder
• MDL Number: MFCD00012622
• NACRES: NA.26
• PubChem ID: 24895420
• Quality Level: 200
• Storage Temperature: 2-8℃