Fmoc-Isn-OH

• CAS: 148928-15-8
• Catalog Number: ACM148928158-1
• Category: Amino Acids
• Molecular Weight: 351.4
• Description: Standard building block for introduction of isonipecotic acid residues by Fmoc SPPS.
• Synonyms: Fmoc-Isn-OH, N-α-Fmoc-piperidine-4-carboxylic acid, Fmoc-Inp-OH
• InChI: 1S/C21H21NO4/c23-20(24)14-9-11-22(12-10-14)21(25)26-13-19-17-7-3-1-5-15(17)16-6-2-4-8-18(16)19/h1-8,14,19H,9-13H2,(H,23,24)
• InChI Key: OJYOOHSQOIDDOO-UHFFFAOYSA-N
• Melting Point: 190 ℃(External MSDS)
• Application: Peptide synthesis.
• Assay: ≥95.0% (acidimetric); ≥98% (TLC); ≥98.0% (HPLC)
• Form: powder
• Functional Group: aromatic amine
• MDL Number: MFCD00273475
• Quality Level: 200
• Reaction Suitability: reaction type: Fmoc solid-phase peptide synthesis
• Storage Temperature: 2-30℃

Synthetic Use

Upstream Synthesis Route 1

• 28920-43-6
• 5984-56-5

• 148928-15-8

Reference: [1]Chemistry - A European Journal,1998,vol. 4,p. 425 - 433

Upstream Synthesis Route 2

• 498-94-2
• 82911-69-1

• 148928-15-8

Reference: [1]Kühl, Nikos; Leuthold, Mila M.; Behnam, Mira A. M.; Klein, Christian D.
[Journal of Medicinal Chemistry, 2021, vol. 64, # 8, p. 4567 - 4587]
[2]Pons, Jean-Francois; Fauchere, Jean-Luc; Lamaty, Frederic; Molla, Annie; Lazaro, Rene
[European Journal of Organic Chemistry, 1998, # 5, p. 853 - 859]

Downstream Synthesis Route 1

• 145013-05-4
• 148928-15-8

• 135322-16-6

Reference: [1] Tetrahedron, 1997, vol. 53, # 19, p. 6697 - 6705

Downstream Synthesis Route 2

• 152120-54-2
• 148928-15-8

• 135322-16-6

Reference: [1] Tetrahedron, 1997, vol. 53, # 19, p. 6697 - 6705

Downstream Synthesis Route 3

• 57260-73-8
• 148928-15-8

• 207725-99-3

Reference: [1]Pons, Jean-Francois; Fauchere, Jean-Luc; Lamaty, Frederic; Molla, Annie; Lazaro, Rene
[European Journal of Organic Chemistry, 1998, # 5, p. 853 - 859]

* For details of the synthesis route, please refer to the original source to ensure accuracy.