Gentamicinsulfate salt

CAS

1403-66-3

Catalog Number

ACM1403663

Category

Main Products

Molecular Weight

477.60

Molecular Formula

C₂₁H₄₃N₅O₇

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Specification

Synonyms

GENTAMYCINE; Gentavet; GentamysinsolutionforBiochemistry; GENTAMYCIN; Gentacycol; Lyramycin; Uromycine; Refobacin tm; GENTAMICINUM;

IUPAC Name

Gentamicin

Boiling Point

669.4ºC at 760 mmHg

Flash Point

358.6ºC

Density

1.3 g/cm³

Appearance

clear amber liquid.

Exact Mass

1389.90000

Comparison of Nephrotoxicity of Gentamicin and Its Nanoparticles in Mice

Jamshidzadeh, Akram, et al. Journal of Biochemical and Molecular Toxicology, 2015, 29(2), 57-62.

Gentamicin is the most kidney damaging aminoglycoside. In this experiment, researchers tried to compare the renal efficacy of gentamicin and a new nanoformulation of the drug in a mouse model. This article demonstrated that gentamicin degenerated the renal proximal tubular cells severely, and induced increases in serum creatinine and BUN. But they did not experience major injury after nano-gentamicin treatment, which suggests that nano-gentamicin is less nephrotoxic.
Nanoparticle Preparation and Loading
· The ionic gelation method involving gentamicin sulfate and sodium alginate was employed to create nanoparticles of a suitable size. An aqueous solution of alginate was prepared, and gentamicin sulfate solution was gradually added while mixing, resulting in nanoparticles of the desired size depending on the proportions used. The preparation process was optimized by adjusting the volume of the drug and maintaining a constant polymer volume at various mixing rates.
· The influence of these different variables on particle size distribution and release profiles was then analyzed. To achieve optimal particle size distribution, an orthogonal factorial design was implemented using Minitab 16 software, resulting in an average nanoparticle size of 80 nm in the optimized formulation. The loading efficiency of the optimized nanoparticles was found to be 85%. Additionally, the physical stability of the particles was deemed acceptable at room temperature and in refrigerated conditions throughout a 3-month study period.

Preparation of Gentamicin-Loaded Nanoparticles and Their Antimicrobial Effects

Abdelghany, Sharif M., et al. International journal of nanomedicine, 2012, 4053-4063.

Gentamicin-loaded poly(lactide-co-glycolide) (PLGA) nanoparticles were developed to achieve controlled release of the antibiotic. Experimental results demonstrated that the antimicrobial efficacy of gentamicin against both planktonic and biofilm infections, both in vitro and in vivo, could be enhanced through optimized encapsulation and release from PLGA nanoparticles.
Preparation of Gentamicin-Loaded PLGA Nanoparticles
A water-in-oil-in-water (w/o/w) emulsion technique was employed for nanoparticle formulation. Gentamicin (3.5 mg) was dissolved in 0.5 mL of water and emulsified with 100 mg of PLGA dissolved in 2 mL of dichloromethane using 20 mV sonication. The primary water-in-oil (w/o) emulsion was then dispersed in 10 mL of aqueous polyvinyl alcohol (PVA) solution (2.5% in 25 mM MES buffer) at varying pH values (5 to 7.4) to form the final w/o/w emulsion.
For solid-in-oil-in-water (s/o/w) formulations, 3.5 mg of gentamicin was dissolved in 0.1 mL of water and added to 2 mL of acetone containing 100 mg of PLGA. As water diffuses into the acetone, solid gentamicin nanoparticles form. This solid phase was added to 10 mL of PVA (2.5% in 25 mM MES buffer) at two pH values (pH 5 and 7.4). The acetone and the aqueous PVA phase combined to coat the gentamicin with PLGA, creating gentamicin-encrusted PLGA nanoparticles.

August 28, 2023

High purity material
The gentamicinsulfate salt purchased on this platform has various specifications, and it has the purity selection that meets its own expectations.

What is the molecular formula of Gentamicinsulfate salt?

The molecular formula of Gentamicinsulfate salt is C60H123N15O21.

What are some synonyms for Gentamicinsulfate salt?

Some synonyms for Gentamicinsulfate salt are Gentamicin sulfate, CHEMBL3039597, BDBM50476074, and G-2419.

When was Gentamicinsulfate salt created and modified?

Gentamicinsulfate salt was created on October 25, 2006, and modified on August 26, 2023.

What is the IUPAC name of Gentamicinsulfate salt?

The IUPAC name of Gentamicinsulfate salt is (2R,3R,4R,5R)-2-[(1S,2S,3R,4S,6R)-4,6-diamino-3-[(2R,3R,6S)-3-amino-6-(1-aminoethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol.

What is the InChI of Gentamicinsulfate salt?

The InChI of Gentamicinsulfate salt is InChI=1S/C21H43N5O7.C20H41N5O7.C19H39N5O7/c1-9(25-3)13-6-5-10(22)19(31-13)32-16-11(23)7-12(24)17(14(16)27)33-20-15(28)18(26-4)21(2,29)8-30-20;1-8(21)12-5-4-9(22)18(30-12)31-15-10(23)6-11(24)16(13(15)26)32-19-14(27)17(25-3)20(2,28)7-29-19;1-19(27)7-28-18(13(26)16(19)24-2)31-15-11(23)5-10(22)14(12(15)25)30-17-9(21)4-3-8(6-20)29-17/h9-20,25-29H,5-8,22-24H2,1-4H3;8-19,25-28H,4-7,21-24H2,1-3H3;8-18,24-27H,3-7,20-23H2,1-2H3/t9?,10-,11+,12-,13+,14+,15-,16-,17+,18-,19-,20-,21+;8?,9-,10+,11-,12+,13+,14-,15-,16+,17-,18-,19-,20+;8-,9+,10-,11+,12-,13+,14+,15-,16+,17+,18+,19-/m110/s1.

What is the InChIKey of Gentamicinsulfate salt?

The InChIKey of Gentamicinsulfate salt is NPEFREDMMVQEPL-RWPARATISA-N.

What is the molecular weight of Gentamicinsulfate salt?

The molecular weight of Gentamicinsulfate salt is 1390.7g/mol.

How many hydrogen bond donor counts does Gentamicinsulfate salt have?

Gentamicinsulfate salt has 24 hydrogen bond donor counts.

How many hydrogen bond acceptor counts does Gentamicinsulfate salt have?

Gentamicinsulfate salt has 36 hydrogen bond acceptor counts.

How many rotatable bond counts does Gentamicinsulfate salt have?

Gentamicinsulfate salt has 19 rotatable bond counts.