Neomycin trisulfate salt hydrate

• CAS: 1405-10-3
• Catalog Number: ACM1405103
• Category: Main Products
• Molecular Weight: 908.88 (anhydrous basis)
• Molecular Formula: C₂₃H₄₆N₆O₁₃·3H₂SO₄·xH₂O
• Synonyms: FradioMycin Sulfate; Neomycin Sulphate; Neomycin trisulfate salt hydrate; Neomycin Sulfate; Neomycin sulfate
• IUPAC Name: Fradiomycin Sulfate
• Boiling Point: 1046.1ºC at 760 mmHg
• Flash Point: 586.5ºC
• Appearance: White or off-white powder
• Exact Mass: 712.28000
• Hazard Statements: Xn
• Safety Description: 23-36/37-45-22-36-24/25
• Stability: Stable. Incompatible with strong oxidizing agents.
• WGK Germany: 3

Case Study

Pharmacokinetic Study of Intravenous and Oral Neomycin Sulfate

Liu, Yu, et al. Journal of veterinary pharmacology and therapeutics, 2021, 44(5), 850-853.

The aminoglycoside antibiotic neomycin is used to treat external or internal bacterial infections and is mainly used in veterinary medicine in the form of its sulfate salt. This work investigated the pharmacokinetic characteristics and absolute availability of neomycin sulfate in swine after a single intravenous and oral dose of 15 mg/kg body weight.
Evaluation methods and results
The blood samples were analyzed using ultra-high-performance liquid chromatography coupled with tandem mass spectrometry (UPLC-MS/MS), and the pharmacokinetic parameters were evaluated through a non-compartmental approach.
In swine, following oral administration, the elimination half-life, mean residence time from the initial time to the last collection point, mean maximum concentration, mean time to reach maximum concentration, and the area under the concentration-time curve from the initial time to the last collection point were recorded as 12.43 ± 7.63 hours, 10.25 ± 4.32 hours, 0.11 ± 0.07 μg/ml, 1.92 ± 0.97 hours, and 1.23 ± 0.78 μg·h/ml, respectively. In contrast, after intravenous administration, these values were 5.87 ± 1.12 hours, 6.07 ± 0.49 hours, 15.80 ± 1.32 μg/ml, 0.30 ± 0.38 hours, and 76.14 ± 3.52 μg·h/ml. The absolute bioavailability of neomycin sulfate B was determined as 4.84% ± 0.03.
In summary, the pharmacokinetic profile indicated a long elimination half-life and a slow clearance rate. The low absolute bioavailability of neomycin sulfate following oral administration suggests that future research could enhance its absorption for treating systemic infections by modifying the dosage form or incorporating adjuvants.

Custom Reviews

August 16, 2023

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A broad-spectrum antibiotic
Neomycin trisulfate salt hydrate is a common antibiotic, and I used the basic structure of neomycin trisulfate salt hydrate to synthesize another highly effective antibiotic.

Custom Q&A

What is the molecular formula of neomycin trisulfate salt hydrate?

The molecular formula of neomycin trisulfate salt hydrate is C23H48N6O17S.

What are some synonyms for neomycin trisulfate salt hydrate?

Some synonyms for neomycin trisulfate salt hydrate include neomycin sulfate, framycetin sulfate, and neobiotic.

What is the chemical structure of neomycin trisulfate salt hydrate?

The chemical structure of neomycin trisulfate salt hydrate is a complex molecule consisting of various amino sugars and a sulfate group.

What are the potential health hazards of neomycin trisulfate salt hydrate?

Neomycin trisulfate salt hydrate is categorized as an irritant and a health hazard.

What is the IUPAC name of neomycin trisulfate salt hydrate?

The IUPAC name of neomycin trisulfate salt hydrate is (2R,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-[(1R,2R,3S,4R,6S)-4,6-diamino-2-[(2S,3R,4S,5R)-4-[(2R,3R,4R,5S,6S)-3-amino-6-(aminomethyl)-4,5-dihydroxyoxan-2-yl]oxy-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-3-hydroxycyclohexyl]oxyoxane-3,4-diol;sulfuric acid.

What is the CAS number of neomycin trisulfate salt hydrate?

The CAS number of neomycin trisulfate salt hydrate is 1405-10-3.

What is the EINECS number of neomycin trisulfate salt hydrate?

The EINECS number of neomycin trisulfate salt hydrate is 248-770-9.

What is the WHO Third International Standard for Neomycin?

The WHO Third International Standard for Neomycin is a standard reference material for neomycin used in pharmaceutical and research applications.

What is the use of neomycin sulfate in microbiological assay?

Neomycin sulfate is used in microbiological assays or tests to determine its potency and effectiveness against specific organisms.

What is the modification date of the reference?

The modification date of the reference is August 26, 2023.