Fmoc-Ser(tBu)-OH

• CAS: 71989-33-8
• Catalog Number: ACM71989338-1
• Category: Amino Acids
• Molecular Weight: 383.44
• Molecular Formula: C22H25NO5
• Description: High purity Fmoc-protected amino acid for research and process production of peptides, with very low levels of dipeptide, free-amino acids and acetic acid impurities.; Standard building block for introduction of serine amino-acid residues by Fmoc SPPS.
• Synonyms: Fmoc-Ser(tBu)-OH, N-α-Fmoc-O-t.-butyl-L-serine
• InChI: 1S/C22H25NO5/c1-22(2,3)28-13-19(20(24)25)23-21(26)27-12-18-16-10-6-4-8-14(16)15-9-5-7-11-17(15)18/h4-11,18-19H,12-13H2,1-3H3,(H,23,26)(H,24,25)/p-1/t19-/m0/s1
• InChI Key: REITVGIIZHFVGU-IBGZPJMESA-M
• Melting Point: 123-130℃
• Application: Peptide synthesis.
• Assay: ≥98% (TLC); ≥98.0% (acidimetric); ≥99.0% (HPLC)
• Form: powder
• Functional Group: hydroxyl
• MDL Number: MFCD00037127
• Quality Level: 400
• Reaction Suitability: reaction type: Fmoc solid-phase peptide synthesis
• Storage Temperature: 2-30℃
• Type: Unlabeled Standard Amino Acids, Serine (Ser)

Synthetic Use

Upstream Synthesis Route 1

• 146346-72-7

• 71989-33-8

Reference: [1] Tetrahedron Letters, 1992, vol. 33, # 49, p. 7605 - 7608
[2] Organic Letters, 2005, vol. 7, # 9, p. 1723 - 1724

Upstream Synthesis Route 2

• 129460-16-8

• 71989-33-8
• 73724-45-5

Reference: [1] Tetrahedron Letters, 2001, vol. 42, # 31, p. 5163 - 5165

Upstream Synthesis Route 3

• 18822-58-7
• 102774-86-7

• 71989-33-8

Reference: [1] Liebigs Annalen der Chemie, 1988, p. 1095 - 1098

Downstream Synthesis Route 1

• 35661-39-3
• 122889-11-6
• 71989-33-8

• 849063-77-0

Reference: [1]Journal of Organic Chemistry,2005,vol. 70,p. 1691 - 1697

* For details of the synthesis route, please refer to the original source to ensure accuracy.