Fmoc-Thr(tBu)-OH

• CAS: 71989-35-0
• Catalog Number: ACM71989350-1
• Category: Amino Acids
• Molecular Weight: 397.46
• Molecular Formula: C23H27NO5
• Description: High purity Fmoc-protected amino acid for research and process production of peptides, with very low levels of dipeptide, free-amino acids and acetic acid impurities.; Standard building block for introduction of threonine amino-acid residues by Fmoc SPPS.
• Synonyms: Fmoc-Thr(tBu)-OH, N-α-Fmoc-O-t.-butyl-L-threonine
• InChI: 1S/C23H27NO5/c1-14(29-23(2,3)4)20(21(25)26)24-22(27)28-13-19-17-11-7-5-9-15(17)16-10-6-8-12-18(16)19/h5-12,14,19-20H,13H2,1-4H3,(H,24,27)(H,25,26)/p-1/t14-,20+/m1/s1
• InChI Key: LZOLWEQBVPVDPR-VLIAUNLRSA-M
• Melting Point: 125-135℃
• Application: Peptide synthesis.
• Assay: ≥98% (TLC); ≥98.0% (acidimetric); ≥99.0% (HPLC)
• Form: powder
• Functional Group: hydroxyl
• MDL Number: MFCD00077075
• Quality Level: 400
• Reaction Suitability: reaction type: Fmoc solid-phase peptide synthesis
• Storage Temperature: 2-30℃
• Type: Unlabeled Standard Amino Acids, Threonine (Thr)

Synthetic Use

Upstream Synthesis Route 1

• 4378-13-6
• 102774-86-7

• 71989-35-0

Reference: [1] Liebigs Annalen der Chemie, 1988, p. 1095 - 1098

Downstream Synthesis Route 1

• 71989-35-0

• 4378-13-6

Reference: [1] Amino Acids, 2014, vol. 46, # 2, p. 367 - 374
[2] Patent: WO2012/136604, 2012, A1, . Location in patent: Page/Page column 42

Downstream Synthesis Route 2

• 71989-35-0

• 4425-82-5
• 4378-13-6

Reference: [1] Chimia, 2010, vol. 64, # 3, p. 200 - 202

* For details of the synthesis route, please refer to the original source to ensure accuracy.