Structure

Fmoc-propargyl-Gly-OH

CAS
198561-07-8
Catalog Number
ACM198561078
Category
Amino Acids
Molecular Weight
335.35
Molecular Formula
C20H17NO4

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Specification

Description
Building block for the introduction by Fmoc SPPS. of an amino acid bearing an alkyne side chain. Such derivatives are useful tools for the synthesis of cyclic peptides by an alkyne-alkyne Glaser coupling, involving Cu(OAc)2/pyridine and heating to 60 ℃using microwaves.
Synonyms
(S)-2-(Fmoc-amino)-4-pentynoic acid, Fmoc-L-2-propargylglycine
Canonical SMILES
OC(=O)[C@H](CC#C)NC(=O)OCC1c2ccccc2-c3ccccc13
InChI
1S/C20H17NO4/c1-2-7-18(19(22)23)21-20(24)25-12-17-15-10-5-3-8-13(15)14-9-4-6-11-16(14)17/h1,3-6,8-11,17-18H,7,12H2,(H,21,24)(H,22,23)/t18-/m0/s1
InChI Key
DJGMNCKHNMRKFM-SFHVURJKSA-N
Application
Peptide synthesis.
Assay
≥98.0% (HPLC)
Beilstein
9151699
Color
white
Form
powder or crystals
Functional Group
Fmoc
MDL Number
MFCD01075095
NACRES
NA.26
PubChem ID
329747060
Quality Level
100
Reaction Suitability
reaction type: Fmoc solid-phase peptide synthesis
Storage Temperature
2-8℃
Type
Unusual Amino Acids, Azide and Alkyne containing Amino Acids
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