Fmoc-Glu(O-2-PhiPr)-OH

• CAS: 200616-39-3
• Catalog Number: ACM200616393-1
• Category: Amino Acids
• Molecular Weight: 487.54
• Description: Quasi-orthogonally-protected Glu derivative. The 2-PhiPr group can be removed selectively in the presence of tBu-based protecting groups by treatment with 1% TFA in DCM , making this derivative an extremely useful tool for the preparation of cyclic peptides by Fmoc SPPS. or for library synthesis. For the on-resin synthesis of side-chain to side-chain lactam bridged peptides, the combination of Lys(Mtt) and Glu(O-2-PhiPr) is particularly advantageous since both side-chains can be simultaneously unmasked in a single step.
• Synonyms: Fmoc-Glu(O-2-PhiPr)-OH, N-α-Fmoc-L-glutamic acid γ-2-phenylisopropyl ester
• InChI: 1S/C29H29NO6/c1-29(2,19-10-4-3-5-11-19)36-26(31)17-16-25(27(32)33)30-28(34)35-18-24-22-14-8-6-12-20(22)21-13-7-9-15-23(21)24/h3-15,24-25H,16-18H2,1-2H3,(H,30,34)(H,32,33)/t25-/m0/s1
• InChI Key: NPNRKQDJIWMHNG-VWLOTQADSA-N
• Application: Peptide synthesis.
• Assay: ≥90.0% (acidimetric); ≥95.0% (HPLC); ≥97% (TLC)
• Form: powder
• Functional Group: carboxylic acid
• Quality Level: 200
• Reaction Suitability: reaction type: Fmoc solid-phase peptide synthesis
• Storage Temperature: 15-25℃