Fmoc-Asp(O-2-PhiPr)-OH

• CAS: 200336-86-3
• Catalog Number: ACM200336863-1
• Category: Amino Acids
• Molecular Weight: 473.52
• Description: Quasi-orthogonally-protected Asp derivative.The 2-PhiPr group can be removed selectively in the presence of tBu-based protecting groups by treatment with 1% TFA in DCM , making this derivative an extremely useful tool for the preparation of cyclic peptides by Fmoc SPPS. or for library synthesis. For the on-resin synthesis of side-chain to side-chain lactam bridged peptides, the combination of Lys(Mtt) and Asp(O-2-PhiPr) is particularly advantageous since both side-chains can be simultaneously unmasked in a single step.This derivative has also been used in solution to prepare bicyclic helix initiating peptides.
• Synonyms: Fmoc-Asp(O-2-PhiPr)-OH, N-α-Fmoc-L-aspartic acid β-2-phenylisopropyl ester
• InChI: 1S/C28H27NO6/c1-28(2,18-10-4-3-5-11-18)35-25(30)16-24(26(31)32)29-27(33)34-17-23-21-14-8-6-12-19(21)20-13-7-9-15-22(20)23/h3-15,23-24H,16-17H2,1-2H3,(H,29,33)(H,31,32)/t24-/m0/s1
• InChI Key: MEAHCBOPNIDLFH-DEOSSOPVSA-N
• Application: Peptide synthesis.
• Assay: ≥93.0% (acidimetric); ≥95.0% (HPLC); ≥97% (TLC)
• Form: powder
• Functional Group: Fmoc
• Quality Level: 200
• Reaction Suitability: reaction type: Fmoc solid-phase peptide synthesis
• Storage Temperature: 15-25℃