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Fmoc-nalpha-methyl-n-im-trityl-l-histidine (FMOC-His(Trt)-OH) is a derivative of the amino acid Histidine. It is used as a building block for the synthesis of peptides and proteins. Histidine is a non-polar, essential amino acid involved in many biological processes such as the biosynthesis of proteins, metal ion binding, and catalysis in enzyme reactions. FMOC-His(Trt)-OH contains a 9-fluorenylmethyloxycarbonyl (Fmoc) protecting group on the amino terminus and a trityl (Trt) protecting group on the imidazole nitrogen.
FMOC-His(Trt)-OH is mainly used as a starting material for the synthesis of peptides and proteins. It is used in SPPS for the incorporation of Histidine residues in the peptide sequence. The resulting peptides and proteins have various applications in scientific experiments, including drug discovery and development, vaccine development, and biological research.