Fmoc-Cys(tButhio)-OH

• CAS: 73724-43-3
• Catalog Number: ACM73724433-1
• Category: Amino Acids
• Molecular Weight: 431.57
• Molecular Formula: C22H25NO4S2
• Description: Building block for introduction of cysteinyl residues by Fmoc SPPS. The t-Buthio group can be selectively removed using thiols or tributylphosphine. This protecting group is stable to TFA if thiol scavengers are not used.
• Synonyms: Fmoc-Cys(tButhio)-OH, N-α-Fmoc-S-t.-butylthio-L-cysteine
• InChI: 1S/C22H25NO4S2/c1-22(2,3)29-28-13-19(20(24)25)23-21(26)27-12-18-16-10-6-4-8-14(16)15-9-5-7-11-17(15)18/h4-11,18-19H,12-13H2,1-3H3,(H,23,26)(H,24,25)/t19-/m0/s1
• InChI Key: ZDUMTHLUTJOUML-IBGZPJMESA-N
• Melting Point: 69-79℃
• Application: Peptide synthesis.
• Assay: ≥95.0% (acidimetric); ≥97.0% (HPLC); ≥98% (TLC)
• Form: powder
• Functional Group: thiol
• MDL Number: MFCD00042617
• Quality Level: 200
• Reaction Suitability: reaction type: Fmoc solid-phase peptide synthesis
• Storage Temperature: 15-25℃
• Type: Unlabeled Standard Amino Acids, Cysteine (Cys)

Synthetic Use

Upstream Synthesis Route 1

• 135248-89-4
• 75-66-1

• 73724-43-3

Reference: [1] Journal of Organic Chemistry, 2010, vol. 75, # 5, p. 1811 - 1813
[2] Protein and Peptide Letters, 2014, vol. 21, # 12, p. 1257 - 1264

Upstream Synthesis Route 2

• 30044-51-0
• 28920-43-6

• 73724-43-3

Reference: [1] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1985, p. 2057 - 2064

Upstream Synthesis Route 3

• 135273-01-7

• 73724-43-3

Reference: [1] Protein and Peptide Letters, 2014, vol. 21, # 12, p. 1257 - 1264

Upstream Synthesis Route 4

• 30044-51-0
• 28920-43-6

• 73724-43-3

Reference: [1]Journal of the Chemical Society. Perkin transactions I,1985,p. 2057 - 2064

Downstream Synthesis Route 1

• 54714-11-3
• 73724-43-3

• 113534-24-0

Reference: [1]Liebigs Annalen der Chemie,1988,p. 437 - 440

* For details of the synthesis route, please refer to the original source to ensure accuracy.