16283-36-6 Purity
96%
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Specification
Immunosuppressed patients can develop skin diseases from opportunistic fungi like Aspergillus fumigatus in its mycelial form and Candida albicans as a yeast form. The research examined how fluorescent brightener 220 (optical brightener 220, OB-220) impacted fungal growth.
· Evaluation Methods
The study grew isolates on agar plates using OB-220 at dosage levels between 0.06 and 11.68 mg/ml. The agar dilution method allowed researchers to determine minimum inhibitory concentrations for OB-220 alongside ketoconazole and fluconazole. The effects of OB-220 treatment on hyphae and yeasts were investigated through fluorescence and transmission electron microscopy compared to control samples. Researchers also performed a toxicity assessment of OB-220 against cells.
· Evaluation Results
OB-220 showed minimal inhibitory concentrations at 1.17-1.46 mg/ml against A. fumigatus and 0.58-1.17 mg/ml against C. albicans with only 0.29 mg/ml needed to inhibit Trichophyton tonsurans. OB-220 treatment resulted in cell wall thickening and blurring of the contours as shown by electron microscopy. OB-220 preserved mammalian cell viability at all tested concentrations up to 11.68 mg/ml. The OB-220 compound disrupted standard chitin formation to prevent fungal growth.
Two sulfonated stilbene derivatives, Fluorescent Brightener 220 (FBA 220) and Fluorescent Brightener 113 (FBA 113), were added to water-based dispersed inkjet inks in different amounts as anti-counterfeiting tags to prepare digital printing inks with excellent stability. These inks can be used for inkjet printing of polyester and polyamide samples.
Ink Formulation and Evaluation
· Table 1 presents water-based ink formulations that comprise 2% (w/v) dye, 70% (v/v) water, a solvent mixture of 20% 2-propanol (IPA) and 5% ethylene glycol (EG) (v/v), 5% (w/v) dispersing agent, and varying percentages of two active agents. Reference formulations lacking the active agents are also included. The components were homogenized for 10 minutes at room temperature using a homogenizer.
· The prepared ink formulations were tested for surface tension, pH, viscosity, and conductivity across 90 days to evaluate ink stability and anti-counterfeiting agent compatibility with other ink components. The findings indicate that the two fluorescent agents can serve as markers in printing pastes to distinguish authentic products from counterfeit ones.
The molecular formula of Fluorescent brightener 220 is C40H40N12Na4O16S4.
The molecular weight of Fluorescent brightener 220 is 1165.0 g/mol.
The IUPAC name of Fluorescent brightener 220 is tetrasodium;5-[[4-[bis(2-hydroxyethyl)amino]-6-(4-sulfonatoanilino)-1,3,5-triazin-2-yl]amino]-2-[(E)-2-[4-[[4-[bis(2-hydroxyethyl)amino]-6-(4-sulfonatoanilino)-1,3,5-triazin-2-yl]amino]-2-sulfonatophenyl]ethenyl]benzenesulfonate.
The InChIKey of Fluorescent brightener 220 is CPZFDTYTCMAAQX-MBCFVHIPSA-J.
The CAS number of Fluorescent brightener 220 is 16470-24-9.
Fluorescent brightener 220 has 8 hydrogen bond donor counts.
Fluorescent brightener 220 has 28 hydrogen bond acceptor counts.
Fluorescent brightener 220 has 20 rotatable bond counts.
The exact mass of Fluorescent brightener 220 is 1164.1158851 g/mol.
The topological polar surface area of Fluorescent brightener 220 is 475?2.