Zinc salicylate

• CAS: 16283-36-6
• Catalog Number: ACM16283366-1
• Category: Main Products
• Molecular Weight: 339.63
• Molecular Formula: C14H10O6Zn
• Synonyms: Benzoic acid, 2-hydroxy-, zinc salt (2:1)
• IUPAC Name: 2-hydroxybenzoicacid;zinc
• Canonical SMILES: C1=CC=C(C(=C1)C(=O)O)O.C1=CC=C(C(=C1)C(=O)O)O.[Zn]
• InChI Key: GSIPEPRFZWZQCN-UHFFFAOYSA-N
• Boiling Point: 336.3ºC at 760mmHg
• Flash Point: 144.5ºC
• Appearance: white needle crystal or powder
• Active Content: 95%
• EC Number: 240-380-7
• Exact Mass: 337.97700
• Hazard Statements: Xn,N
• Physical State: Solid
• Safety Description: S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .; S36/39:Wear suitable protective clothing and eye/face protection .; S60:This material and/or its container must be disposed of as hazardous waste .; S61:Avoid
• WGK Germany: 2

Case Study

Zinc Salicylate for Marine Antifouling Coatings

Bellotti, Natalia, et al. Industrial & Engineering Chemistry Research, 2014, 53(38), 14559-14564.

A novel bioactive product obtained from salicylic acid, zinc salicylate (ZnSal), was evaluated for use in antifouling coatings.
· Evaluation Methods
The bioactivity of ZnSal was initially assessed using Artemia larvae assays in preliminary experiments. In the next phase, soluble matrix coatings were created using two different binders: rosin/oleic acid and rosin/styrene-acrylate copolymers. The leaching rate of these coatings in artificial seawater was measured prior to their immersion in natural conditions. Finally, the antifouling effectiveness of the coatings was tested in field trials.
· Performance of Zinc Salicylate-Based Coatings
ZnSal demonstrated bioactivity against Artemia larvae while exhibiting lower toxicity compared to copper. Coating 1 outperformed coating 2 in longevity, maintaining a fouling rating above 95 for up to twelve months of immersion. The formulation with ZnSal and a rosin/oleic acid binder showed acceptable efficiency for over 12 months. Although the use of a styrene-acrylate copolymer in coating 2 improved resistance to wear relative to coating 1, it compromised antifouling performance due to a reduced leaching rate. Field test results confirmed that ZnSal is a viable and effective antifoulant.

Effects of Zinc Salicylate on Airway Smooth Muscle Cell Remodeling

Fang, Lei, et al. The Journal of Nutritional Biochemistry, 2021, 89, 108563.

This study investigated the effects of zinc salicylate-methylsulfonylmethane (Zn-Sal-MSM) compared with zinc salicylate (Zn-Sal), sodium salicylate (Na-Sal), or zinc chloride (ZnCl2) on human airway smooth muscle cell (ASMC) remodeling parameters.
Proposed action mechanism of zinc salicylate
· Zn-Sal-MSM and Zn-Sal along with Na-Sal reduced PDGF-BB-induced cell proliferation in a dose-dependent way at concentrations between 0.1 to 100 µg/mL but ZnCl2 demonstrated toxic effects. The reduction in cell proliferation occurred alongside increased expression of the cell cycle inhibitor p21(Waf1/Cip1) and reduced activities of Akt, p70S6K, and Erk1/2 signaling pathways.
· Although both Zn-Sal-MSM and Zn-Sal reduced the accumulation of fibronectin and collagen type-I, Na-Sal did not have this effect. Additionally, Zn-Sal-MSM led to a decrease in the mitochondria-specific COX4 expression. Mass spectrometry analysis revealed that Zn-Sal-MSM altered the expression levels of several signaling proteins and zinc-dependent enzymes.
· In summary, Zn-Sal-MSM and Zn-Sal may help prevent airway wall remodeling in asthma by inhibiting both Erk1/2 and mTOR signaling pathways.