Eltrombopag

• CAS: 496775-61-2
• Catalog Number: ACM496775612
• Category: Inhibitors
• Molecular Weight: 442.47
• Molecular Formula: C₂₅H₂₂N₄O₄
• Description: Eltrombopag (SB-497115) is an orally active thrombopoietin receptor nonpeptide agonist. Eltrombopag owns thrombopoietic activity, and has been used to research low blood platelet counts with chronic immune thrombocytopenia. Eltrombopag can be used for the research of cardiovascular. Eltrombopag also has highly inhibitory effects against multidrug resistant Staphylococcus aureus. Eltrombopag can induce apoptosis in hepatocellular carcinomab (HCC) as well.
• Synonyms: Eltrombopag;3-[2-[(2Z)-1-(3,4-Dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazinyl]-2-hydroxy-[1,1-biphenyl]-3-carboxylic acid;(1,1-Biphenyl)-3-carboxylic acid, 3-((2Z)-(1-(3,4-dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene)hydrazino)-2-hydroxy-;Eltrombopag [inn];Promacta;Sb497115;Sb-497115;Unii-S56D65xj9g
• Canonical SMILES: O=C(C1=CC(C2=CC=CC(N/N=C3C(C)=NN(C4=CC=C(C)C(C)=C4)C/3=O)=C2O)=CC=C1)O
• Melting Point: 242-244°C
• Density: 1.33
• Appearance: Solid
• Storage: Powder-20°C, 3 years; 4°C, 2 years; In solvent-80°C, 6 months; -20°C, 1 month.
• Shipping: Can be shipped at room temperature, where not in use may vary.

Custom Q&A

What is the molecular formula of Eltrombopag?

The molecular formula of Eltrombopag is C25H22N4O4.

What is the molecular weight of Eltrombopag?

The molecular weight of Eltrombopag is 442.5 g/mol.

What is another name for Eltrombopag?

Another name for Eltrombopag is SB497115.

What is the chemical structure of Eltrombopag?

The chemical structure of Eltrombopag contains a hydrazine with substituted nitrogen atoms by specific groups.

What is the primary physiological target of Eltrombopag?

The primary physiological target of Eltrombopag is the c-mpl (TpoR) receptor, which is the physiological target of the hormone thrombopoietin.

What condition is Eltrombopag used to treat in adults?

Eltrombopag is used to treat low blood platelet counts in adults with chronic immune (idiopathic) thrombocytopenia (ITP).

What is the mechanism of action of Eltrombopag?

The mechanism of action of Eltrombopag is as a Thrombopoietin Receptor Agonist.

What other condition was Eltrombopag recently approved for in 2012?

Eltrombopag was recently approved in 2012 for the treatment of thrombocytopenia in patients with chronic hepatitis C to allow them to initiate and maintain interferon-based therapy.

What are some of the physiological effects of Eltrombopag?

The physiological effects of Eltrombopag include Increased Megakaryocyte Maturation and Increased Platelet Production.

What are some identifiers for Eltrombopag in various databases?

Some identifiers for Eltrombopag include CAS number 496775-61-2, UNII code S56D65XJ9G, and ChEMBL IDs CHEMBL461101, CHEMBL478463, and CHEMBL3186485.