3,5-Diiodo-L-thyronine

• CAS: 1041-01-6
• Catalog Number: ACM1041016-2
• Category: Main Products
• Molecular Weight: 525.08
• Molecular Formula: C15H13I2NO4
• Synonyms: Diiodothyronine
• IUPAC Name: (2S)-2-Amino-3-[4-(4-hydroxyphenoxy)-3,5-diiodophenyl]propanoic acid
• Canonical SMILES: C1=CC(=CC=C1O)OC2=C(C=C(C=C2I)CC(C(=O)O)N)I
• InChI: InChI=1S/C15H13I2NO4/c16-11-5-8(7-13(18)15(20)21)6-12(17)14(11)22-10-3-1-9(19)2-4-10/h1-6,13,19H,7,18H2,(H,20,21)/t13-/m0/s1
• InChI Key: ZHSOTLOTTDYIIK-ZDUSSCGKSA-N
• Boiling Point: 559.4±50.0 °C
• Melting Point: 255-260 °C
• Flash Point: 292.1 °C
• Density: 2.095±0.06 g/cm³
• Appearance: Solid
• Storage: Keep in dark place, sealed in dry, store in freezer, under -20 °C
• Complexity: 365
• EC Number: 213-867-7
• Exact Mass: 524.89340
• Hazard Statements: Xn
• Isomeric SMILES: C1=CC(=CC=C1O)OC2=C(C=C(C=C2I)C[C@@H](C(=O)O)N)I
• Monoisotopic Mass: 524.89340
• pKa: 2.15±0.30(Predicted)
• Refractive Index: 1.726
• Safety Description: 24/25
• Topological Polar Surface Area: 92.8 Ų
• WGK Germany: 3

Case Study

Physiological Effects of 3,5-Diiodo-L-Thyronine in Dietary Supplements

Hernandez A. Endocrinology, 2015, 156(1), 5-7.

3,5-Diiodo-L-thyronine (T2) is a thyroid hormone (TH) metabolite that has found its way into the formulations of many drugs. 3,5-Diiodo-L-thyronine was observed to have rapid induction of hepatic oxygen consumption and oxidative capacity and was therefore used as a metabolic inducer. Outlined below are some of the physiological effects that T2 may have as a dietary supplement ingredient.
Physiological Effects of 3,5-Diiodo-L-Thyronine
· T2 has positive effects on mitochondrial function, fat mass, lipid metabolism, and insulin resistance, supporting the use of T2 to enhance metabolism.
· Although T2's ability to increase metabolism is unquestionable, it is unclear which conditions allow its safe and effective use in humans.
· The researchers used an obese mouse model to analyze the physiological effects of T2. These effects include inhibition of the HPT axis, reductions in fat mass, serum leptin, and cholesterol, and increases in lean body mass, food intake, and hepatic expression of TH-dependent genes related to lipid metabolism.
· In addition, studies have shown that in addition to increasing metabolism and reducing fat mass, T2 administration can lead to HPT axis suppression, increased food intake, and cardiac hypertrophy.

Custom Reviews

July 21, 2024

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Highly Effective in Regulating Gene Activity
3,5-Diiodo-L-thyronine from Alfa Chemistry to be a highly effective product in regulating gene activity. The off-white solid compound is easy to work with and has provided promising results in my studies related to homeostasis, lipid metabolism, and insulin resistance. I have also found it to be useful in the early detection and treatment of congenital or drug-induced hypothyroidism. Overall, I highly recommend this product for anyone conducting research in the field of thyroid hormones and gene regulation.

Synthetic Use

Upstream Synthesis Route 1

• 178877-78-6

• 1041-01-6

Reference: [1] Synthetic Communications, 2013, vol. 43, # 10, p. 1439 - 1446

Upstream Synthesis Route 2

• 54337-43-8
• 300-39-0

• 1041-01-6

Reference: [1] Tetrahedron Letters, 1997, vol. 38, # 40, p. 6965 - 6968

Upstream Synthesis Route 3

• 623-05-2

• 1041-01-6

Reference: [1] Tetrahedron Letters, 1997, vol. 38, # 40, p. 6965 - 6968

Downstream Synthesis Route 1

• 1041-01-6

• 51-48-9

Reference: [1]Patent: WO2015/151013,2015,A1 .Location in patent: Page/Page column 14

Downstream Synthesis Route 2

• 1041-01-6

• 6893-02-3

Reference: [1]Biochemical Journal,1953,vol. 53,p. 645,647
[2]Biochemical Journal,1953,vol. 53,p. 645,647
[3]Biochemical Journal,1953,vol. 53,p. 645,647
[4]Organic Process Research and Development,2014,vol. 18,p. 1175 - 1180
[5]Patent: JP5833222,2015,B2

* For details of the synthesis route, please refer to the original source to ensure accuracy.