CB-103

• CAS: 218457-67-1
• Catalog Number: ACM218457671-1
• Category: Inhibitors
• Molecular Weight: 242.32
• Molecular Formula: C15H18N2O
• Description: CB-103 is a γ-secretase inhibitor. CB-103 inhibits Notch signaling in primary human T cell acute lymphoblastic leukemia and other Notch-dependent human tumor cell lines, and concomitantly induces cell cycle arrest and apoptosis, thereby impairing proliferation, including in GSI-resistant human tumor cell lines with chromosomal translocations and rearrangements in Notch genes. CB-103 produces Notch loss-of-function phenotypes in flies and mice and inhibits the growth of human breast cancer and leukemia xenografts, notably without causing the dose-limiting intestinal toxicity associated with other Notch inhibitors.
• Synonyms: CB-103; CB 103; CB103
• IUPAC Name: 5-Amino-2-(4-tert-butylphenoxy)pyridine
• Canonical SMILES: CC(C)(C)C1=CC=C(C=C1)OC2=NC=C(C=C2)N
• InChI: InChI=1S/C15H18N2O/c1-15(2,3)11-4-7-13(8-5-11)18-14-9-6-12(16)10-17-14/h4-10H,16H2,1-3H3
• InChI Key: WHIWGRCYMQLLAO-UHFFFAOYSA-N
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Shelf Life: >2 years if stored properly
• Storage: Dry, dark and at 0-4 °C for short term (days to weeks) or -20 °C for long term (months to years).
• Drug Formulation: This drug may be formulated in DMSO
• Elemental Analysis: C, 74.35; H, 7.49; N, 11.56; O, 6.60
• Exact Mass: 242.1419
• HS Tariff Code: 2934.99.9001
• Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
• Stock Solution Storage: 0-4 °C for short term (days to weeks), or -20 °C for long term (months).